Bemcentinib (CAS 1037624-75-1)
Alternate Names:
R428 R 428 R-428 BGB324 BGB-324 BGB 324
CAS Number:
1037624-75-1
Molecular Weight:
506.60
Molecular Formula:
C30H34N8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Bemcentinib (CAS 1037624-75-1) References
- AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction. | Landolt, L., et al. 2019. Physiol Rep. 7: e14091. PMID: 31134766
- ADAMTSL5 is an epigenetically activated gene underlying tumorigenesis and drug resistance in hepatocellular carcinoma. | Arechederra, M., et al. 2021. J Hepatol. 74: 893-906. PMID: 33197513
- Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model. | Hoel, A., et al. 2021. J Cell Mol Med. 25: 7407-7417. PMID: 34219376
- Bemcentinib and Gilteritinib Inhibit Cell Growth and Impair the Endo-Lysosomal and Autophagy Systems in an AXL-Independent Manner. | Zdżalik-Bielecka, D., et al. 2022. Mol Cancer Res. 20: 446-455. PMID: 34782372
- AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model. | Chen, TJ., et al. 2021. Physiol Rep. 9: e15140. PMID: 34877810
- AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells. | Li, H., et al. 2022. Cell Rep Med. 3: 100554. PMID: 35492873
- Inhibition of a new AXL isoform, AXL3, induces apoptosis of mantle cell lymphoma cells. | Gelebart, P., et al. 2023. Blood. 142: 1478-1493. PMID: 37339584
- Targeting CD301+ macrophages inhibits endometrial fibrosis and improves pregnancy outcome. | Lv, H., et al. 2023. EMBO Mol Med. 15: e17601. PMID: 37519221
- The promising impact of Bemcentinib and Repotrectinib on sleep impairment in Alzheimer's disease. | Ariaei, A. and Ramezani, F. 2023. J Biomol Struct Dyn. 1-17. PMID: 37909502
- Evaluation of the Role of AXL in Fusion-positive Pediatric Rhabdomyosarcoma Identifies the Small-molecule Inhibitor Bemcentinib (BGB324) as Potent Chemosensitizer. | Danielli, SG., et al. 2024. Mol Cancer Ther. 23: 864-876. PMID: 38471796
Inhibitor of:
AFP, Axl, CARD 12, Gas6, GIPC, MOX-1, NLR family CARD domain-containing (NLRC), Olfr549, Pbx 2, TDAG8, and Tyro3.Activator of:
Integrin α8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bemcentinib, 10 mg | sc-507363 | 10 mg | $900.00 |