Molecular structure of (−)-Bebeerine, CAS Number: 436-05-5
(−)-Bebeerine (CAS 436-05-5)
Alternate Names:
Curine
Application:
(−)-Bebeerine is an alkaloid that interacts with nAChR
CAS Number:
436-05-5
Molecular Weight:
594.70
Molecular Formula:
C36H38N2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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(-)-Bebeerine is a cyclic natural product alkaloid. (-)-Bebeerine is described to noncompetitively block neuromuscular transmission through interaction with the nicotinic acetylcholine receptor. (-)-Bebeerine is also described as an identifier of extracts from Cissampelos pareira roots which contain high concentrations of this alkaloid.
(−)-Bebeerine (CAS 436-05-5) References
- Natural probes for cholinergic sites: L-bebeerine actions on the neuromuscular transmission, the nicotinic receptor/ionic channel complex, and contraction of skeletal muscles. | Souccar, C., et al. 1999. Acta Physiol Pharmacol Ther Latinoam. 49: 268-78. PMID: 10797870
- Comparative phytochemical investigation of the sources of ayurvedic drug patha: a chromatographic fingerprinting analysis. | Hullatti, KK. and Sharada, MS. 2010. Indian J Pharm Sci. 72: 39-45. PMID: 20582188
- Curine, a bisbenzylisoquinoline alkaloid, blocks L-type Ca²⁺ channels and decreases intracellular Ca²⁺ transients in A7r5 cells. | Medeiros, MA., et al. 2011. Eur J Pharmacol. 669: 100-7. PMID: 21872583
- Curine inhibits eosinophil activation and airway hyper-responsiveness in a mouse model of allergic asthma. | Ribeiro-Filho, J., et al. 2013. Toxicol Appl Pharmacol. 273: 19-26. PMID: 23994558
- Curine inhibits mast cell-dependent responses in mice. | Ribeiro-Filho, J., et al. 2014. J Ethnopharmacol. 155: 1118-24. PMID: 24969825
- Effects of curine in HL-60 leukemic cells: cell cycle arrest and apoptosis induction. | Dantas, BB., et al. 2015. J Nat Med. 69: 218-23. PMID: 25616501
- Anti-allergic properties of curine, a bisbenzylisoquinoline alkaloid. | Ribeiro-Filho, J., et al. 2015. Molecules. 20: 4695-707. PMID: 25781071
- Effect of Temperature on 1H NMR Spectra, Antitrypanosomal Activity, Conformational Analysis, and Molecular Docking of Curine Derivatives from Berberis brevissima. | Ali, S., et al. 2020. J Nat Prod. 83: 1383-1393. PMID: 32364734
- Effects of Two Natural Bisbenzylisoquinolines, Curine and Guattegaumerine, Extracted from Isolona hexaloba on Rhodamine Efflux by Abcb1b from Rat Glycocholic-Acid-Resistant Hepatocarcinoma Cells. | Sergent, JA., et al. 2022. Molecules. 27: PMID: 35566380
- Effects of Verapamil and Two Bisbenzylisoquinolines, Curine and Guattegaumerine Extracted from Isolona hexaloba, on the Inhibition of ABC Transporters from Pseudomonas aeruginosa. | Hulen, C., et al. 2022. Antibiotics (Basel). 11: PMID: 35625344
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(−)-Bebeerine, 5 mg | sc-363277 | 5 mg | $1035.00 |