Molecular structure of BD 1063 dihydrochloride, CAS Number: 150208-28-9
BD 1063 dihydrochloride (CAS 206996-13-6)
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Alternate Names:
1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride
Application:
BD 1063 dihydrochloride is an σ1 receptor antagonist and selective over σ2 sites
CAS Number:
206996-13-6
Purity:
≥98%
Molecular Weight:
346.13
Molecular Formula:
C13H18Cl2N2•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
σ1 receptor antagonist, which is approximately 50-fold selective over σ2 sites and ≥100-fold selective over opioid, PCP, muscarinic, dopamine, α1, α2, β adrenoceptor, 5-HT1 and 5-HT2 receptors. This prevents hyperlocomotion following cocaine administration in mice.σ1 receptor antagonist, which is approximately 50-fold selective over σ2 sites and ≥100-fold selective over opioid, PCP, muscarinic, dopamine, α1, α2, β adrenoceptor, 5-HT1 and 5-HT2 receptors. This prevents hyperlocomotion following cocaine administration in mice.
BD 1063 dihydrochloride (CAS 206996-13-6) References
- Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells. | Cobos, EJ., et al. 2007. J Neurochem. 102: 812-25. PMID: 17419803
- The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. | Sabino, V., et al. 2009. Neuropsychopharmacology. 34: 1482-93. PMID: 18946467
- Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. | Lever, JR., et al. 2014. J Pharmacol Exp Ther. 351: 153-63. PMID: 25100754
- Modulation of mesenteric collecting lymphatic contractions by σ1-receptor activation and nitric oxide production. | Trujillo, AN., et al. 2017. Am J Physiol Heart Circ Physiol. 313: H839-H853. PMID: 28778917
- Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion. | Nakamura, Y., et al. 2019. Elife. 8: PMID: 31596232
- 3,4-Methylenedioxypyrovalerone High-Responder Phenotype as a Tool to Evaluate Candidate Medications for Stimulant Use Disorder. | Doyle, MR., et al. 2023. J Pharmacol Exp Ther. 384: 353-362. PMID: 36627204
- Network medicine approaches for identification of novel prognostic systems biomarkers and drug candidates for papillary thyroid carcinoma. | Kori, M., et al. 2023. J Cell Mol Med. 27: 4171-4180. PMID: 37859510
- Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist. | Liu, C., et al. 2024. J Biol Chem. 300: 107219. PMID: 38522516
- Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis. | Chen, W., et al. 2024. Arch Toxicol.. PMID: 38896176
- Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism. | Matsumoto, RR., et al. 1995. Eur J Pharmacol. 280: 301-10. PMID: 8566098
Inhibitor of:
DRP1, and Sigma Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BD 1063 dihydrochloride, 10 mg | sc-203838 | 10 mg | $148.00 | |||
BD 1063 dihydrochloride, 50 mg | sc-203838A | 50 mg | $510.00 | |||
BD 1063 dihydrochloride, 1.5 g | sc-203838B | 1.5 g | $5100.00 | |||
BD 1063 dihydrochloride, 2 g | sc-203838C | 2 g | $5814.00 | |||
BD 1063 dihydrochloride, 3 g | sc-203838D | 3 g | $6664.00 |