Molecular structure of BD 1047 dihydrobromide, CAS Number: 138356-21-5
BD 1047 dihydrobromide (CAS 138356-21-5)
See product citations (4)
Alternate Names:
2-(3,4-Dichlorophenyl)-N-(2-dimethylaminoethyl)-N-methylethanamine dihydrobromide
Application:
BD 1047 dihydrobromide is an σ1 receptor antagonist with higher affinity than BD 1063
CAS Number:
138356-21-5
Purity:
≥99%
Molecular Weight:
437.04
Molecular Formula:
C13H20CI2N2•2HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BD 1047 dihydrobromide serves as a selective and potent antagonist targeting the sigma-1 receptor, a chaperone protein embedded within various cellular mechanisms. The molecular interaction of BD 1047 dihydrobromide with the sigma-1 receptor involves the inhibition of ligand binding, showcasing a high affinity toward this receptor. This compound is instrumental in elucidating the sigma-1 receptor′s involvement across a range of physiological and pathological states. By selectively blocking this receptor, BD 1047 dihydrobromide enables researchers to dissect the multifaceted roles of sigma-1 in modulating cellular functions, providing insights into its underlying biological pathways and potential implications in various cellular processes.
BD 1047 dihydrobromide (CAS 138356-21-5) References
- Effects of trazodone on neurotransmitter release from rat mossy fibre cerebellar synaptosomes. | Garrone, B., et al. 2000. Eur J Pharmacol. 400: 35-41. PMID: 10913582
- Involvement of the sigma1 receptor in the cocaine-induced conditioned place preference. | Romieu, P., et al. 2000. Neuroreport. 11: 2885-8. PMID: 11006959
- Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice. | Kim, HC., et al. 2003. Life Sci. 72: 769-83. PMID: 12479976
- Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin. | Cervo, L., et al. 2005. Eur Neuropsychopharmacol. 15: 211-8. PMID: 15695067
- The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. | Shin, EJ., et al. 2005. Br J Pharmacol. 144: 908-18. PMID: 15723099
- Intrathecal treatment with sigma1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice. | Kim, HW., et al. 2006. Br J Pharmacol. 148: 490-8. PMID: 16682960
- Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats. | Shin, EJ., et al. 2007. Neurochem Int. 50: 791-9. PMID: 17386960
- Stereoselective action of (+)-morphine over (-)-morphine in attenuating the (-)-morphine-produced antinociception via the naloxone-sensitive sigma receptor in the mouse. | Wu, HE., et al. 2007. Eur J Pharmacol. 571: 145-51. PMID: 17617400
- The sigma receptor agonist SA4503 both attenuates and enhances the effects of methamphetamine. | Rodvelt, KR., et al. 2011. Drug Alcohol Depend. 116: 203-10. PMID: 21277708
- Straub tail reaction in mice treated with σ(1) receptor antagonist in combination with methamphetamine. | Kitanaka, J., et al. 2012. Brain Res. 1482: 40-6. PMID: 22981417
- Stimulation of sigma receptors with afobazole blocks activation of microglia and reduces toxicity caused by amyloid-β25-35. | Behensky, AA., et al. 2013. J Pharmacol Exp Ther. 347: 458-67. PMID: 24006337
- Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage. | Shimazawa, M., et al. 2015. Exp Eye Res. 132: 64-72. PMID: 25616094
- M100907 and BD 1047 attenuate the acute toxic effects of methamphetamine. | Ray, A., et al. 2019. Neurotoxicology. 74: 91-99. PMID: 31163210
- Experimental Study of Antidepressant Properties of Afobazole. | Kapitsa, IG., et al. 2023. Bull Exp Biol Med.. PMID: 37338764
- Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism. | Matsumoto, RR., et al. 1995. Eur J Pharmacol. 280: 301-10. PMID: 8566098
Inhibitor of:
ABCD4, ATP5B, Sig-1R, and Sigma Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BD 1047 dihydrobromide, 10 mg | sc-203837 | 10 mg | $142.00 | |||
BD 1047 dihydrobromide, 50 mg | sc-203837A | 50 mg | $597.00 |