Molecular structure of BCTC, CAS Number: 393514-24-4
BCTC (CAS 393514-24-4)
See product citations (6)
Application:
BCTC is an effective and potent TRPV1 channel antagonist
CAS Number:
393514-24-4
Purity:
≥98%
Molecular Weight:
372.9
Molecular Formula:
C20H25ClN4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BCTC is an effective and potent transient receptor potential VR1 (vanilloid-1, TRPV1) channel antagonist. VR1 (TRPV1) is a Capsaicin (sc-3577) receptor that behaves as a non-selective cation channel that is mainly found in the sensory neurons, and specifically detects painful stimuli, low pH and heat. Studies show that BCTC and Capsazepine (sc-201098) both inhibit the activation of rat VR1 (vanilloid receptor 1), induced with acid or Capsaicin. Other VR1 (TRPV1) antagonists include AMG9810 (sc-201477) and SB705498. BCTC is an inhibitor of ANKTM1 and TRPM8.
BCTC (CAS 393514-24-4) References
- N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain. | Pomonis, JD., et al. 2003. J Pharmacol Exp Ther. 306: 387-93. PMID: 12721336
- N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties. | Valenzano, KJ., et al. 2003. J Pharmacol Exp Ther. 306: 377-86. PMID: 12721338
- TRPV1 splice variants: structure and function. | Schumacher, MA. and Eilers, H. 2010. Front Biosci (Landmark Ed). 15: 872-82. PMID: 20515731
- Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath. | Tékus, V., et al. 2010. Eur J Pharmacol. 641: 135-41. PMID: 20534382
- Enhanced insulin secretion and sensitization in diabetic mice on chronic treatment with a transient receptor potential vanilloid 1 antagonist. | Tanaka, H., et al. 2011. Life Sci. 88: 559-63. PMID: 21277869
- Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC. | Benko, R., et al. 2012. Eur J Pharmacol. 674: 44-50. PMID: 22056835
- Functional roles of transient receptor potential melastatin 8 (TRPM8) channels in the cold stress-induced detrusor overactivity pathways in conscious rats. | Lei, Z., et al. 2013. Neurourol Urodyn. 32: 500-4. PMID: 23001687
- Synthesis of Analogues of BCTC Incorporating a Pyrrolidinyl Linker and Biological Evaluation as Transient Receptor Potential Vanilloid 1 Antagonists. | Yan, L., et al. 2016. Chem Biol Drug Des. 87: 306-11. PMID: 26360809
- 3-Iodothyronamine increases transient receptor potential melastatin channel 8 (TRPM8) activity in immortalized human corneal epithelial cells. | Lucius, A., et al. 2016. Cell Signal. 28: 136-147. PMID: 26689735
- Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. | Liu, T., et al. 2016. Oncol Lett. 11: 182-188. PMID: 26870186
- Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis. | Lian, YL., et al. 2017. Mol Med Rep. 16: 1920-1926. PMID: 28627595
- Effects of Cinnamaldehyde on Smooth Muscle Preparations. | Sandor, ZI., et al. 2019. Pharmacology. 104: 207-211. PMID: 31302651
- Pharmacological and genetic inhibition of TRPC6-induced gene transcription. | Scheuble, J., et al. 2020. Eur J Pharmacol. 886: 173357. PMID: 32758574
- TRPM8 Channel Promotes the Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells. | Henao, JC., et al. 2021. Front Cell Dev Biol. 9: 592946. PMID: 33614639
- Gallic Acid Inhibits Mesaconitine-Activated TRPV1-Channel-Induced Cardiotoxicity. | Han, S., et al. 2022. Evid Based Complement Alternat Med. 2022: 5731372. PMID: 35463061
Inhibitor of:
ANKTM1, TRPM8, and VR1.Activator of:
VRL-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BCTC, 10 mg | sc-205599 | 10 mg | $179.00 | |||
BCTC, 50 mg | sc-205599A | 50 mg | $724.00 |