Molecular structure of Bcr-abl Inhibitor III, CAS Number: 778277-15-9
Bcr-abl Inhibitor III (CAS 778277-15-9)
Alternate Names:
Abl Inhibitor III; N-(2-Hydroxyethyl)-3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide
Application:
Bcr-abl Inhibitor III is a suppressor of the proliferation of Bcr-abl-expressing Ba/F3
CAS Number:
778277-15-9
Purity:
≥97%
Molecular Weight:
418.37
Molecular Formula:
C20H17F3N4O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bcr-abl Inhibitor III is a cell-permeable GNF-2 N-hydroxyethyl carboxamide analog that exhibits in vivo efficacy in suppressing the proliferation of Bcr-abl-expressing Ba/F3 and bone marrow cells in murine xenograft models of leukemia. Bcr-abl Inhibitor III exerts its effect via an allosteric mechanism (IC50 of 0.22 muM) by targeting the myristate-binding pocket near the c-terminus of Abl kinase domain and thereby altering the conformational dynamics of the ATP-binding pocket. Bcr-abl Inhibitor III is ineffective toward the myristate-binding site mutant E505K and the ATP-binding site ′gatekeeper′ mutant T315I. Bcr-abl Inhibitor III is an inhibitor of c-Abl (Bcr-abl).
Bcr-abl Inhibitor III (CAS 778277-15-9) References
- Role of Abl in airway hyperresponsiveness and airway remodeling. | Cleary, RA., et al. 2013. Respir Res. 14: 105. PMID: 24112389
Inhibitor of:
c-Abl, Cbl-b, HNF-1α, SOAT1, and Tyro3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bcr-abl Inhibitor III, 10 mg | sc-364428 | 10 mg | $113.00 |