Bcl-xL Antibody (44): sc-136207
- Bcl-xL Antibody (44) is a mouse monoclonal IgG1, cited in 9 publications, provided at 50 µg/0.5 ml
- raised against amino acids 18-233 of Bcl-xL of human origin
- recommended for detection of Bcl-xL of mouse, rat and human origin by WB, IP and IF; not recommended for IP
- See Bcl-xL (H-5): sc-8392 for Bcl-xL antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bcl-xL Antibody (44). This work is in progress.
Bcl-xL Antibody (44) is a mouse monoclonal IgG1 antibody that detects Bcl-xL in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Bcl-xL plays a crucial role in regulating apoptosis, acting as a potent inhibitor of programmed cell death, which is vital for maintaining cellular homeostasis and preventing excessive cell loss in various tissues. Bcl-xL is primarily located in the mitochondria, where anti-Bcl-xL antibody (44) can detect interactions with pro-apoptotic proteins that modulate apoptotic signaling pathways. The balance between Bcl-xL and antagonists, such as Bad and Bax, is essential for determining cell fate, particularly in hematopoietic cells, where dysregulation can lead to conditions like cancer. Bcl-xL′s ability to form heterodimers with these proteins underscores its importance in the apoptotic process, as Bcl-xL can sequester pro-apoptotic factors and inhibit their function, thereby promoting cell survival. Bcl-xL monoclonal antibody (44) serves as an invaluable tool for researchers studying apoptosis and its implications in various diseases, including cancer, where the modulation of cell death pathways is a critical area of investigation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bcl-xL Antibody (44) | sc-136207 | 50 µg/0.5 ml | $322.00 |