Bcl-xL Antibody (44): sc-136207
- Bcl-xL Antibody (44) is a mouse monoclonal IgG1, cited in 9 publications, provided at 50 µg/0.5 ml
- raised against amino acids 18-233 of Bcl-xL of human origin
- recommended for detection of Bcl-xL of mouse, rat and human origin by WB, IP and IF; not recommended for IP
- See Bcl-xL (H-5): sc-8392 for Bcl-xL antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bcl-xL Antibody (44). This work is in progress.
Bcl-xL Antibody (44) is a mouse monoclonal IgG1 antibody that detects Bcl-xL in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Bcl-xL plays a crucial role in regulating apoptosis, acting as a potent inhibitor of programmed cell death, which is vital for maintaining cellular homeostasis and preventing excessive cell loss in various tissues. Bcl-xL is primarily located in the mitochondria, where anti-Bcl-xL antibody (44) can detect interactions with pro-apoptotic proteins that modulate apoptotic signaling pathways. The balance between Bcl-xL and antagonists, such as Bad and Bax, is essential for determining cell fate, particularly in hematopoietic cells, where dysregulation can lead to conditions like cancer. Bcl-xL′s ability to form heterodimers with these proteins underscores its importance in the apoptotic process, as Bcl-xL can sequester pro-apoptotic factors and inhibit their function, thereby promoting cell survival. Bcl-xL monoclonal antibody (44) serves as an invaluable tool for researchers studying apoptosis and its implications in various diseases, including cancer, where the modulation of cell death pathways is a critical area of investigation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Bcl-xL Antibody (44) References:
- Bcl-xL overexpression restricts gamma-radiation-induced apoptosis. | Wang, ZB., et al. 2006. Cell Biol Int. 30: 15-20. PMID: 16253528
- Bcl-xl does not have to bind Bax to protect T cells from death. | Liu, X., et al. 2006. J Exp Med. 203: 2953-61. PMID: 17158961
- Bcl-XL inhibits membrane permeabilization by competing with Bax. | Billen, LP., et al. 2008. PLoS Biol. 6: e147. PMID: 18547146
- Bcl-xL is a dominant antiapoptotic protein that inhibits homoharringtonine-induced apoptosis in leukemia cells. | Yin, S., et al. 2011. Mol Pharmacol. 79: 1072-83. PMID: 21415308
- Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints. | Wang, J., et al. 2011. Cell Signal. 23: 2030-8. PMID: 21840391
- Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737. | Renault, TT., et al. 2015. Int J Biochem Cell Biol. 64: 136-46. PMID: 25862283
- Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors. | Nakamura, A., et al. 2016. J Neurosci. 36: 5448-61. PMID: 27194326
- Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. | Chung, CW., et al. 2020. ACS Chem Biol. 15: 2316-2323. PMID: 32697072
- Bcl-xL overexpression decreases GILZ levels and inhibits glucocorticoid-induced activation of caspase-8 and caspase-3 in mouse thymocytes. | Muscari, I., et al. 2020. J Transl Autoimmun. 3: 100035. PMID: 32803151
- Artificial intelligence-based identification of octenidine as a Bcl-xL inhibitor. | Bui, ATN., et al. 2022. Biochem Biophys Res Commun. 588: 97-103. PMID: 34953212
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bcl-xL Antibody (44) | sc-136207 | 50 µg/0.5 ml | $322.00 |