Bcl-rambo Antibody (6D161): sc-70416

Bcl-rambo Antibody (6D161) is a mouse monoclonal IgG1 antibody that detects Bcl-rambo in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Bcl-rambo plays a crucial role in the regulation of apoptosis, a programmed cell death process essential for maintaining cellular homeostasis and eliminating damaged cells. Anti-Bcl-rambo antibody (6D161) targets this protein primarily in the mitochondria, where Bcl-rambo exerts pro-apoptotic effects. The mitochondrial localization is significant because Bcl-rambo interacts directly with key components of the apoptotic machinery, facilitating the release of cytochrome c from the mitochondria into the cytosol, which is a critical step in the activation of caspases and the execution of apoptosis. Bcl-rambo′s unique C-terminal region, which contains two tandem repeats preceding the membrane anchor, distinguishes Bcl-rambo from other Bcl-2 family members and is essential for function. By understanding the localization and function of Bcl-rambo, researchers can gain insights into the mechanisms of apoptosis and implications in various diseases, including cancer, where dysregulation of apoptotic pathways is often observed. Bcl-rambo monoclonal antibody (6D161) serves as an invaluable tool for studying these processes in human tissues.

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Bcl-rambo Antibody (6D161) References:

1. Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension.  |  Kataoka, T., et al. 2001. J Biol Chem. 276: 19548-54. PMID: 11262395
2. Bcl-rambo beta, a special splicing variant with an insertion of an Alu-like cassette, promotes etoposide- and Taxol-induced cell death.  |  Yi, P., et al. 2003. FEBS Lett. 534: 61-8. PMID: 12527362
3. Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator.  |  Kim, JY., et al. 2012. FEBS Lett. 586: 3142-9. PMID: 22921587
4. The Human Bcl-2 Family Member Bcl-rambo Localizes to Mitochondria and Induces Apoptosis and Morphological Aberrations in Drosophila.  |  Nakazawa, M., et al. 2016. PLoS One. 11: e0157823. PMID: 27348811
5. The human Bcl-2 family member Bcl-rambo and voltage-dependent anion channels manifest a genetic interaction in Drosophila and cooperatively promote the activation of effector caspases in human cultured cells.  |  Matsubara, H., et al. 2019. Exp Cell Res. 381: 223-234. PMID: 31102594
6. Selective binding of mitophagy receptor protein Bcl-rambo to LC3/GABARAP family proteins.  |  Li, M., et al. 2020. Biochem Biophys Res Commun. 530: 292-300. PMID: 32828302
7. BCL2L13: physiological and pathological meanings.  |  Meng, F., et al. 2021. Cell Mol Life Sci. 78: 2419-2428. PMID: 33201252
8. Corrigendum to: The human Bcl-2 family member Bcl-rambo and voltage-dependent anion channels manifest a genetic interaction in Drosophila and cooperatively promote the activation of effector caspases in human cultured cells.  |  Matsubara, H., et al. 2021. Exp Cell Res. 405: 112711. PMID: 34217518
9. PGAM5 interacts with Bcl-rambo and regulates apoptosis and mitophagy.  |  Hashino, T., et al. 2022. Exp Cell Res. 420: 113342. PMID: 36075447
10. The BCL-2 family protein BCL-RAMBO interacts and cooperates with GRP75 to promote its apoptosis signaling pathway.  |  Xu, J., et al. 2023. Sci Rep. 13: 14041. PMID: 37640805

The preferred Bcl-rambo antibody is Bcl-rambo Antibody (G-9): sc-390598.