Bcl-7b Antibody (NQ-B25): sc-134278

Bcl-7b Antibody (NQ-B25) is a mouse monoclonal IgG1 kappa light chain antibody that detects Bcl-7b of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Bcl-7b antibody (NQ-B25) is available as a non-conjugated format. Bcl-7b, also known as B-cell CLL/lymphoma 7B, consists of 202 amino acids and exists in multiple alternatively spliced isoforms, which adds complexity to functional roles. Bcl-7b is expressed ubiquitously and participates in critical cellular processes such as cell cycle regulation and apoptosis, making Bcl-7b significant in tumorigenesis, particularly in lung cancer. Bcl-7b haploinsufficiency is associated with cardiovascular and musculoskeletal abnormalities seen in Williams-Beuren syndrome. Bcl-7b can interact with immunoglobulin E (IgE) in patients with atopic dermatitis, suggesting a potential role as an autoantigen and involvement in allergic responses. The gene encoding Bcl-7b is located on human chromosome 7, a region harboring over 1,000 genes linked to several genetic disorders, including Osteogenesis imperfecta and Shwachman-Diamond syndrome. These multifaceted roles in both normal physiology and disease underscore Bcl-7b importance as a target for research and therapeutic interventions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Bcl-7b Antibody (NQ-B25) References:

1. The neurobiology of Williams syndrome: cascading influences of visual system impairment?  |  Eckert, MA., et al. 2006. Cell Mol Life Sci. 63: 1867-75. PMID: 16810457
2. Williams-Beuren syndrome diagnosis using fluorescence in situ hybridization.  |  Osborne, LR., et al. 2006. Methods Mol Med. 126: 113-28. PMID: 16930009
3. Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon.  |  Zani, VJ., et al. 1996. Blood. 87: 3124-34. PMID: 8605326
4. Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci.  |  Liang, H., et al. 1998. Proc Natl Acad Sci U S A. 95: 3781-5. PMID: 9520444
5. Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients.  |  Natter, S., et al. 1998. FASEB J. 12: 1559-69. PMID: 9806765
6. Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes.  |  Meng, X., et al. 1998. Hum Genet. 103: 590-9. PMID: 9860302
7. The BCL7 gene family: deletion of BCL7B in Williams syndrome.  |  Jadayel, DM., et al. 1998. Gene. 224: 35-44. PMID: 9931421

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Bcl-7b Antibody (NQ-B25) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Bcl-7b Antibody (NQ-B25) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Bcl-7b Antibody (NQ-B25) Specifications

Alternate Product Name: BCL7B

Product Clone Name: NQ-B25

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 124-203

Epitope Target: Bcl-7b

Epitope Species: human

Product Reactivity/Detection: Bcl-7b

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Bcl-7b Antibody (NQ-B25): N/A