Bcl-2 Antibody (4C11): sc-578

Bcl-2 Antibody (4C11) is a rat monoclonal IgG2c antibody that detects Bcl-2 in mouse and rat samples through applications such as immunoprecipitation, immunofluorescence, and enzyme-linked immunosorbent assay. Bcl-2 is a crucial regulator of apoptosis, playing a significant role in cell survival and development by preventing programmed cell death. This anti-apoptotic, membrane-associated oncoprotein interacts with various members of the Bcl-2 family, including both death suppressors like Bcl-xL and Mcl-1, as well as death agonists such as Bax and Bak. These interactions are vital for maintaining cellular homeostasis and protecting against diseases, including cancer, where the normal apoptotic processes are disrupted. The functionality of Bcl-2 is further modulated by post-translational modifications, including phosphorylation and proteolytic processing, which can enhance or inhibit activity. By stabilizing the mitochondrial membrane and interfering with the cytochrome c/Apaf-1 pathway, Bcl-2 effectively promotes cell survival, making Bcl-2 a key player in the balance between life and death in cells. Mutations in the Bcl-2 gene can lead to an overexpression of Bcl-2, contributing to the development of various cancers by allowing cells to evade the normal mechanisms of apoptosis. Bcl-2 (4C11) monoclonal antibody is an essential tool for researchers studying the intricate pathways of cell survival and death, providing insights into the molecular mechanisms underlying cancer and other diseases.

The preferred Bcl-2 antibody is Bcl-2 Antibody (C-2): sc-7382.