Date published: 2025-12-16

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BC 11 hydrobromide (CAS 443776-49-6)

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Alternate Names:
Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide
Application:
BC 11 hydrobromide is a selective inhibitor of urokinase (uPA)
CAS Number:
443776-49-6
Molecular Weight:
290.97
Molecular Formula:
C8H11BN2O2S•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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BC 11 hydrobromide (BC 11 HBr) is a potent organic compound employed in scientific research. It is derived from 11-bromo-1-undecanol (BC 11), an aliphatic alcohol in the form of its hydrobromide salt. This white solid substance can dissolve in water and ethanol, with a melting point of approximately 125°C. It finds widespread use in studies investigating biochemical and physiological effects, as well as in both in vitro and in vivo experiments. In vitro experiments entail employing cell cultures, whereas in vivo experiments involve live animals. BC 11 hydrobromide, being an aliphatic alcohol derivative, is believed to serve as a substrate for various enzymes involved in lipid and carbohydrate metabolism. Moreover, it is thought to interact with multiple proteins, including those participating in signal transduction pathways.


BC 11 hydrobromide (CAS 443776-49-6) References

  1. Colorectal cancer-promoting activity of the senescent peritoneal mesothelium.  |  Mikuła-Pietrasik, J., et al. 2015. Oncotarget. 6: 29178-95. PMID: 26284488
  2. Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching.  |  Semina, E., et al. 2016. Eur J Cell Biol. 95: 295-310. PMID: 27324124
  3. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases.  |  Mikuła-Pietrasik, J., et al. 2016. Cell Death Dis. 7: e2565. PMID: 28032864
  4. Protective, repairing and fibrinolytic effects of rivaroxaban on vascular endothelium.  |  Álvarez, E., et al. 2018. Br J Clin Pharmacol. 84: 280-291. PMID: 28940408
  5. Pirfenidone inhibits motility of NSCLC cells by interfering with the urokinase system.  |  Krämer, M., et al. 2020. Cell Signal. 65: 109432. PMID: 31693876
  6. Epidermal growth factor receptor regulates fibrinolytic pathway elements in cervical cancer: functional and prognostic implications.  |  Gomes, FG., et al. 2021. Braz J Med Biol Res. 54: e10754. PMID: 33886813
  7. Fibrin-mediated growth restriction of early-stage human trophoblasts is switched to growth promotion through fibrinolysis.  |  Asano, Y., et al. 2021. Hum Reprod. 36: 3108-3121. PMID: 34597378
  8. The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation.  |  Vorstandlechner, V., et al. 2021. Nat Commun. 12: 6242. PMID: 34716325
  9. BC-11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS-CoV-2 host cell entry.  |  Moumbock, AFA., et al. 2023. Arch Pharm (Weinheim). 356: e2200371. PMID: 36316225

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

BC 11 hydrobromide, 10 mg

sc-362712
10 mg
$306.00

BC 11 hydrobromide, 50 mg

sc-362712A
50 mg
$1224.00