Molecular structure of BC 11-38, CAS Number: 686770-80-9
BC 11-38 (CAS 686770-80-9)
Alternate Names:
6,7-Dihydro-3-phenyl-2-(propylthio)-thieno[3,2-d]pyrimidin-4(3H)-one
Application:
BC 11-38 is a selective inhibitor of phosphodiesterase 11
CAS Number:
686770-80-9
Purity:
≥98%
Molecular Weight:
304.43
Molecular Formula:
C15H16N2OS2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BC 11-38 is a remarkable molecule renowned for its ability to stabilize cyclic nucleotide phosphodiesterase, an enzyme pivotal in the breakdown of the vital second messenger cyclic adenosine monophosphate (cAMP) within cells. As a regulator of cellular function, cAMP plays a significant role in various physiological processes. Notably, in vivo experiments have revealed its ability to impede the growth and metastasis of cancer cells. Additionally, BC 11-38 exhibits cognitive-enhancing effects by elevating cAMP levels. Another attribute of BC 11-38 is its capacity to inhibit PDE5 enzymes.
BC 11-38 (CAS 686770-80-9) References
- PDE5 Inhibitors as Potential Tools in the Treatment of Cystic Fibrosis. | Noel, S., et al. 2012. Front Pharmacol. 3: 167. PMID: 23024633
- The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment. | Fajardo, AM., et al. 2014. Cancers (Basel). 6: 436-58. PMID: 24577242
- Cyclic AMP and glycogen synthase kinase 3 form a regulatory loop in spermatozoa. | Dey, S., et al. 2018. J Cell Physiol. 233: 7239-7252. PMID: 29574946
- Interaction of AIP with protein kinase A (cAMP-dependent protein kinase). | Schernthaner-Reiter, MH., et al. 2018. Hum Mol Genet. 27: 2604-2613. PMID: 29726992
- Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics. | Tyagi, R., et al. 2019. Sci Rep. 9: 9085. PMID: 31235822
- Suppression of Proliferation of Human Glioblastoma Cells by Combined Phosphodiesterase and Multidrug Resistance-Associated Protein 1 Inhibition. | Kopanitsa, L., et al. 2021. Int J Mol Sci. 22: PMID: 34575827
Inhibitor of:
PDE11A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BC 11-38, 10 mg | sc-364350 | 10 mg | $224.00 | |||
BC 11-38, 50 mg | sc-364350A | 50 mg | $667.00 |