BBS6 Antibody (F-8): sc-390077

BBS6 Antibody (F-8) is a mouse monoclonal IgM antibody that detects BBS6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). BBS6 (F-8) antibody is available as the non-conjugated form. BBS6 plays a crucial role in the assembly and function of cilia, which are essential for various cellular processes, including signaling pathways and cellular motility. Dysfunction in cilia can lead to a range of disorders, collectively known as ciliopathies, which include Bardet-Biedl syndrome (BBS). BBS is a complex genetic disorder characterized by symptoms such as obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delays. Patients with BBS are also at an increased risk for developing diabetes, hypertension, and congenital heart defects. BBS6, classified as a Group II chaperonin-like protein, is primarily localized to the pericentriolar material (PCM), a critical region surrounding centrioles that is vital for cilia formation and function. During interphase, BBS6 is found on the lateral surfaces of the PCM, but redistributes throughout the PCM during mitosis, highlighting its dynamic role in cellular processes. BBS6′s ability to interact with other proteins involved in ciliary function underscores its importance in maintaining cellular homeostasis and the potential implications of its dysfunction in disease.

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BBS6 Antibody (F-8) References:

1. Genetic and mutational analyses of a large multiethnic Bardet-Biedl cohort reveal a minor involvement of BBS6 and delineate the critical intervals of other loci.  |  Beales, PL., et al. 2001. Am J Hum Genet. 68: 606-16. PMID: 11179009
2. Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus.  |  Badano, JL., et al. 2003. Hum Mol Genet. 12: 1651-9. PMID: 12837689
3. Variation of the McKusick-Kaufman gene and studies of relationships with common forms of obesity.  |  Andersen, KL., et al. 2005. J Clin Endocrinol Metab. 90: 225-30. PMID: 15483080
4. Antenatal presentation of Bardet-Biedl syndrome may mimic Meckel syndrome.  |  Karmous-Benailly, H., et al. 2005. Am J Hum Genet. 76: 493-504. PMID: 15666242
5. Ocular phenotypes of three genetic variants of Bardet-Biedl syndrome.  |  Héon, E., et al. 2005. Am J Med Genet A. 132A: 283-7. PMID: 15690372
6. MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis.  |  Kim, JC., et al. 2005. J Cell Sci. 118: 1007-20. PMID: 15731008
7. [Update on Bardet-Biedl syndrome].  |  Dollfus, H., et al. 2005. J Fr Ophtalmol. 28: 106-12. PMID: 15767906
8. Testing for triallelism: analysis of six BBS genes in a Bardet-Biedl syndrome family cohort.  |  Hichri, H., et al. 2005. Eur J Hum Genet. 13: 607-16. PMID: 15770229
9. No evidence for triallelic inheritance of MKKS/BBS loci in Amish Mckusick-Kaufman syndrome.  |  Nakane, T. and Biesecker, LG. 2005. Am J Med Genet A. 138: 32-4. PMID: 16104012

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BBS6 Antibody (F-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-BBS6 Antibody (F-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BBS6 Antibody (F-8) Specifications

Alternate Product Name: BBS6

Product Clone Name: F-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 14-37

Epitope Target: BBS6

Epitope Species: human

Product Reactivity/Detection: BBS6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for BBS6 Antibody (F-8): P: Blocking Peptide, X: TransCruz Reagent