Bazedoxifene Bis-β-D-Glucuronide (CAS 328933-67-1)

Bazedoxifene Bis-β-D-Glucuronide is a glucuronide conjugate of the parent compound bazedoxifene, a selective estrogen receptor modulator (SERM). This metabolite is primarily formed through the phase II metabolic pathway known as glucuronidation, a process where glucuronic acid is added to a substance, enhancing its solubility and facilitating its excretion from the body. In research contexts, Bazedoxifene Bis-β-D-Glucuronide is particularly useful for studying the metabolism and excretion mechanisms of bazedoxifene and related SERMs. The double glucuronidation indicates a higher polarity and solubility, making it an ideal marker for understanding the dynamics of drug clearance and the role of the uridine 5′-diphospho-glucuronosyltransferase (UGT) enzyme family in drug metabolism. Researchers utilize this metabolite to explore how SERMs are processed in different biological systems, aiding in the prediction of pharmacokinetic behaviors such as distribution, half-life, and potential accumulation in tissues. By analyzing Bazedoxifene Bis-β-D-Glucuronide, scientists gain insights into the safety and efficacy profiles of SERMs, contributing to the broader field of drug development by highlighting how structural changes affect metabolic pathways and elimination profiles in pharmacological studies.