Molecular structure of BAY-u 9773, CAS Number: 154978-38-8
BAY-u 9773 (CAS 154978-38-8)
Alternate Names:
6(R)-(4-Carboxyphenylthio)-5(S)-hydroxy-7(E),9(E),11(E),14(Z)-eicosatetraenoic acid
Application:
BAY-u 9773 is a cysteinyl leukotriene receptor antagonist
CAS Number:
154978-38-8
Molecular Weight:
472.6
Molecular Formula:
C27H36O5S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BAY-u 9773 is a cysteinyl leukotriene receptor antagonist which displays equal affinity towards CysLT1 and CysLT2 receptors. This inhibitory action suppresses bronchial and venous muscle contractions in human muscle preparations. Alternate studies demonstrate that BAY-u 9773 inhibits eosinophil infiltration in airway walls. BAY-u 9773 inhibits water up-regulation by aquaporin 4, via antagonism of the CysLT2 receptor. The permeability of cysteinyl leukotriene receptors across transendothelial membranes is reduced upon addition of BAY-u 9773. Furthermore,this compound acts as a competitive antagonist towards LTC4 and LTE4 receptors, which leads to contractions in trachea of guinea pig models.
BAY-u 9773 (CAS 154978-38-8) References
- The ACh-induced contraction in rat aortas is mediated by the Cys Lt1 receptor via intracellular calcium mobilization in smooth muscle cells. | Mazzetti, L., et al. 2003. Br J Pharmacol. 138: 707-15. PMID: 12598425
- A second cysteinyl leukotriene receptor in human lung. | Labat, C., et al. 1992. J Pharmacol Exp Ther. 263: 800-5. PMID: 1331415
- Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport. | Moos, MP., et al. 2008. FASEB J. 22: 4352-62. PMID: 18779380
- CysLT2 receptor-mediated AQP4 up-regulation is involved in ischemic-like injury through activation of ERK and p38 MAPK in rat astrocytes. | Qi, LL., et al. 2011. Life Sci. 88: 50-6. PMID: 21055410
- Effects of a cysteinyl leukotriene dual 1/2 receptor antagonist on antigen-induced airway hypersensitivity and airway inflammation in a guinea pig asthma model. | Muraki, M., et al. 2011. Int Arch Allergy Immunol. 155 Suppl 1: 90-5. PMID: 21646802
- Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction. | Lenz, QF., et al. 2014. Neuroscience. 277: 859-71. PMID: 25090924
- Evidence that ABC transporter-mediated autocrine export of an eicosanoid signaling molecule enhances germ cell chemotaxis in the colonial tunicate Botryllus schlosseri. | Kassmer, SH., et al. 2020. Development. 147: PMID: 32665242
- Trichomonas vaginalis-secreted cysteinyl leukotrienes promote migration, degranulation and MCP-1 production in mast cells. | Lee, YA., et al. 2020. Parasite Immunol. 42: e12789. PMID: 32881004
- The anti-seizure potential of cysteine leukotriene receptor antagonists: A systematic review of animal studies. | Bano, A., et al. 2024. Epilepsy Res. 200: 107305. PMID: 38325237
Inhibitor of:
CysLT2 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAY-u 9773, 50 µg | sc-203835 | 50 µg | $155.00 |