Molecular structure of BAY-u 3405, CAS Number: 116649-85-5
BAY-u 3405 (CAS 116649-85-5)
Alternate Names:
Ramatroban
Application:
BAY-u 3405 is a suppresor PGD2-induced migration of human eosinophils
CAS Number:
116649-85-5
Purity:
>98%
Molecular Weight:
416.47
Molecular Formula:
C21H21FN2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
BAY-u 3405 suppresses PGD2-induced migration of human eosinophils (IC50 = 170 nM). It is a potent dual antagonist of TXA2R (TP)/DP2 (CRTH2) prostanoid receptors (Ki values are 4.3, 4.5 and > 10000 nM for hDP2, hTP and hDP1 receptors respectively). This prevents the activation of downstream signaling pathways that lead to inflammation. BAY-u 3405 has been found to inhibit the activity of pro-inflammatory enzymes like cyclooxygenase-2 (COX-2) and the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha).
BAY-u 3405 (CAS 116649-85-5) References
- Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. | Sundström, E., et al. 2003. J Pharmacol Exp Ther. 307: 408-18. PMID: 12954791
- Receptor binding properties of the new and specific thromboxane receptor antagonist Bay U 3405. | Darius, H., et al. 1992. Agents Actions Suppl. 37: 157-61. PMID: 1385923
- Binding characteristics of the new thromboxane A2/prostaglandin H2 receptor antagonist [3H]BAY U 3405 to washed human platelets and platelet membranes. | Theis, JG., et al. 1992. Biochem Pharmacol. 44: 495-503. PMID: 1387312
- Ramatroban (BAY u 3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor. | Ishizuka, T., et al. 2004. Cardiovasc Drug Rev. 22: 71-90. PMID: 15179446
- Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. | Ulven, T. and Kostenis, E. 2005. J Med Chem. 48: 897-900. PMID: 15715457
- Effect of BAY U 3405, a new thromboxane antagonist, on sudden death in rabbits. | Seuter, F., et al. 1991. J Lipid Mediat. 3: 283-8. PMID: 1773029
- Mechanism of the protective action of Bay-u-3405, a new specific thromboxane receptor antagonist, in arachidonate-induced sudden death. | Ma, XL., et al. 1991. Methods Find Exp Clin Pharmacol. 13: 105-10. PMID: 1906568
- Improved coronary thrombolysis by tissue-type plasminogen activator in the presence of BAY U 3405. | Rounding, HP. and Fiedler, VB. 1991. Eur J Pharmacol. 198: 207-10. PMID: 1907562
- Characterization of Bay U 3405, a novel thromboxane A2/endoperoxide receptor antagonist. | Perzborn, E., et al. 1990. Stroke. 21: IV143-5. PMID: 2148034
- Effect of Bay U 3405, a new thromboxane antagonist, on collagen-induced thromboembolism in rabbits. | Seuter, F., et al. 1990. Stroke. 21: IV146-8. PMID: 2260139
- Effects of the novel thromboxane antagonist Bay U 3405 on experimental coronary artery disease. | Fiedler, VB., et al. 1990. Stroke. 21: IV149-51. PMID: 2260140
- Bay U 3405 inhibits cerebral vasospasm induced by authentic thromboxane A2. | Braun, M. and Schrör, K. 1990. Stroke. 21: IV152-4. PMID: 2260141
- Protective effects of BAY U 3405, a thromboxane A2 receptor antagonist, in endotoxin shock. | Altavilla, D., et al. 1994. Pharmacol Res. 30: 137-51. PMID: 7816742
- Effects of thromboxane A2 receptor antagonist (Bay u 3405) on nasal symptoms after antigen challenge in sensitized guinea pigs. | Narita, S., et al. 1996. Int Arch Allergy Immunol. 109: 161-6. PMID: 8563491
- The effect of a thromboxane A2 receptor antagonist BAY-u-3405 on experimental allergic reactions. | Nagai, H., et al. 1995. Prostaglandins. 50: 75-87. PMID: 8588075
Inhibitor of:
DP2, PGD, TXA Synthase, and TXA2R.Activator of:
DP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAY-u 3405, 10 mg | sc-203834 | 10 mg | $189.00 | |||
BAY-u 3405, 50 mg | sc-203834A | 50 mg | $797.00 |