BAY 61-3606 hydrochloride
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BAY 61-3606 hydrochloride stands out as a highly specific and effective modulator within the sphere of biochemical research, targeting the spleen tyrosine kinase (Syk) with remarkable precision. Its cell-permeable nature ensures efficient access to intracellular Syk, facilitating its role in investigating the intricate pathways mediated by this kinase. With a Ki value of 7.5 nM, it underscores its potent inhibitory action exclusively on Syk tyrosine kinase activity, without affecting other tyrosine kinases like Btk, Fyn, Itk, Lyn, and Src. This selectivity not only underscores its utility in dissecting the specific contributions of Syk to cellular signaling and function but also in elucidating the diverse mechanisms by which Syk influences various biological processes.
BAY 61-3606 hydrochloride References
- Dectin-1/Syk signaling is involved in Lactobacillus casei cell wall extract-induced mouse model of Kawasaki disease. | Lin, IC., et al. 2013. Immunobiology. 218: 201-12. PMID: 22633994
- Vascular endothelial growth factor-a in lactobacillus casei cell wall extract-induced coronary arteritis of a murine model. | Lin, IC., et al. 2014. Circ J. 78: 752-62. PMID: 24334707
- Identification of compounds that modulate retinol signaling using a cell-based qHTS assay. | Chen, Y., et al. 2016. Toxicol In Vitro. 32: 287-96. PMID: 26820057
- A spleen tyrosine kinase inhibitor attenuates the proliferation and migration of vascular smooth muscle cells. | Seo, HH., et al. 2017. Biol Res. 50: 1. PMID: 28100269
- β-Arrestin1 and GPCR kinase2 play permissive roles in Src-mediated endocytosis of α4β2 nicotinic ACh receptors. | Acharya, S., et al. 2021. Br J Pharmacol. 178: 3498-3516. PMID: 33844281
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAY 61-3606 hydrochloride, 5 mg | sc-360240 | 5 mg | $284.00 | |||
BAY 61-3606 hydrochloride, 25 mg | sc-360240A | 25 mg | $1056.00 |