Barnidipine HCl (CAS 104757-53-1)
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Barnidipine HCl is a dihydropyridine calcium channel blocker that functions by inhibiting the influx of calcium ions into cardiac and smooth muscle. It targets L-type calcium channels in particular, blocking the entry of calcium ions into the cells. This inhibition leads to relaxation of vascular smooth muscle and a reduction in systemic vascular resistance, resulting in decreased blood pressure. By blocking calcium channels, Barnidipine HCl interferes with the excitation-contraction coupling of smooth muscle cells, ultimately leading to vasodilation. Barnidipine HCl′s mechanism of action involves binding to the alpha-1 subunit of the L-type calcium channel, thereby preventing the channel from opening and inhibiting calcium influx.
Barnidipine HCl (CAS 104757-53-1) References
- Determination of barnidipine in human serum and dog plasma by HPLC with electrochemical detection. | Takamura, K., et al. 1995. Biol Pharm Bull. 18: 1311-4. PMID: 8593428
- [Effect of barnidipine hydrochloride on the autonomic nervous system: difference between short- and long-acting components of calcium antagonist]. | Soejima, K., et al. 1997. J Cardiol. 30: 13-8. PMID: 9253691
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Barnidipine HCl, 10 mg | sc-357293B | 10 mg | $20.00 | |||
Barnidipine HCl, 100 mg | sc-357293 | 100 mg | $124.00 | |||
Barnidipine HCl, 1 g | sc-357293A | 1 g | $417.00 |