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BAPTA, Tetrasodium Salt (CAS 126824-24-6)

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Alternate Names:
BAPTA-Na4; Tetrasodium 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetate
Application:
BAPTA, Tetrasodium Salt is a high quality and sensitive compound for calcium signaling studies
CAS Number:
126824-24-6
Molecular Weight:
564.36
Molecular Formula:
C22H20N2O104Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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BAPTA, Tetrasodium Salt (1,2-Bis(2-aminophenoxy)ethane-N,N,N#39,N#39-tetraacetic acid tetrasodium salt) is a selective calcium chelator with 105-fold greater affinity for Ca2+ than for Mg2+. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research. When BAPTA forms complexes with Ca2+, a UV spectrum shift from 254 to 279 nm occurs at pH >6.0. BAPTA, Tetrasodium Salt is useful for spectrophotometric monitoring of extracellular Ca2+ levels, with very little sensitivity to pH. Has also been used for the measurement and control of Ca2+ levels in eggs, chromaffin cells, muscle cells, retinal cells, and pancreatic cells. Neuroprotective effects in vitro against excitotoxic damage and spontaneous recurrent seizures, such as epilepsy have also been observed. Additional BAPTA chelators available: BAPTA, Free Acid (sc-201508) BAPTA tetrapotassium salt (sc-202076) BAPTA/AM (sc-202488) BAPTA-APM (sc-206966) BAPTA-TMFM (sc-212043) 5,5i difluoro Bapta(AM) (sc-217247) 5,5i difluoro Bapta(K+ Salt) (sc-217248) Bapta-FF (AM) (sc-217696)


BAPTA, Tetrasodium Salt (CAS 126824-24-6) References

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  3. Distinct regulation of expressed calcium channels 2.3 in Xenopus oocytes by direct or indirect activation of protein kinase C.  |  Kamatchi, GL., et al. 2003. Brain Res. 968: 227-37. PMID: 12663092
  4. Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C.  |  Qiu, J., et al. 2003. J Neurosci. 23: 9529-40. PMID: 14573532
  5. Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors.  |  Vanhoose, AM., et al. 2006. J Neurosci. 26: 1138-45. PMID: 16436600
  6. Postsynaptic and presynaptic effects of the calcium chelator BAPTA on synaptic transmission in rat hippocampal dentate granule neurons.  |  Niesen, C., et al. 1991. Brain Res. 555: 319-25. PMID: 1657301
  7. Robust pacemaking in substantia nigra dopaminergic neurons.  |  Guzman, JN., et al. 2009. J Neurosci. 29: 11011-9. PMID: 19726659
  8. Leptin excites proopiomelanocortin neurons via activation of TRPC channels.  |  Qiu, J., et al. 2010. J Neurosci. 30: 1560-5. PMID: 20107083
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  11. Properties of neuroprotective cell-permeant Ca2+ chelators: effects on [Ca2+]i and glutamate neurotoxicity in vitro.  |  Tymianski, M., et al. 1994. J Neurophysiol. 72: 1973-92. PMID: 7823112
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

BAPTA, Tetrasodium Salt, 250 mg

sc-278716
250 mg
$77.00

BAPTA, Tetrasodium Salt, 500 mg

sc-278716A
500 mg
$186.00