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BAPTA tetrapotassium salt (CAS 73630-08-7) - chemical structure image
Molecular structure of BAPTA tetrapotassium salt, CAS Number: 73630-08-7
BAPTA tetrapotassium salt (CAS 73630-08-7) - chemical structure image
Molecular structure of BAPTA tetrapotassium salt, CAS Number: 73630-08-7
Molecular structure of BAPTA tetrapotassium salt, CAS Number: 73630-08-7

BAPTA tetrapotassium salt (CAS 73630-08-7)

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Alternate Names:
1,2-bis(2-Aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrapotassium salt; BAPTA⋅4K
Application:
BAPTA tetrapotassium salt is a selective calcium chelator with greater affinity for Ca2+ than Mg2+
CAS Number:
73630-08-7
Purity:
≥98%
Molecular Weight:
628.79
Molecular Formula:
C22H20K4N2O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

BAPTA tetrapotassium salt (1,2-bis-(o-Aminophenoxy)-ethane-N,N,N′,N′-tetraacetic acid•4K) is a selective calcium chelator with 105-fold greater affinity for Ca2+ than for Mg2+. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction including apoptotic cascades, and neuroscience research. BAPTA and its derivatives are calcium chelators used to form calcium buffers with well-defined calcium concentrations. BAPTA free acid is not cell permeable and is useful for manipulating extracellular Ca2+ levels. BAPTA is closely related to the well-known chelator EGTA [ethylene glycol bis(beta-aminoethyl ether)-N,N,N′,N′-tetraacetic acid] (sc-3593), but is less effected by pH changes and are more efficient at taking up and releasing Ca2+. Additional BAPTA chelators available: BAPTA, Free Acid (sc-201508) BAPTA/AM (sc-202488) BAPTA-APM (sc-206966) BAPTA-TMFM (sc-212043) 5,5i difluoro Bapta(AM) (sc-217247) 5,5i difluoro Bapta(K+ Salt) (sc-217248) Bapta-FF (AM) (sc-217696) BAPTA, Tetrasodium Salt (sc-278716)


BAPTA tetrapotassium salt (CAS 73630-08-7) References

  1. 1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid (BAPTA-AM) inhibits caffeine-induced apoptosis in human neuroblastoma cells.  |  Jang, MH., et al. 2004. Neurosci Lett. 358: 189-92. PMID: 15039113
  2. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA.  |  Hardie, RC. 2005. Cell Calcium. 38: 547-56. PMID: 16140375
  3. Tonic activation of GABAB receptors reduces release probability at inhibitory connections in the cerebellar glomerulus.  |  Mapelli, L., et al. 2009. J Neurophysiol. 101: 3089-99. PMID: 19339456
  4. ATP stimulates rat hypothalamic sympathetic neurons by enhancing AMPA receptor-mediated currents.  |  Ferreira-Neto, HC., et al. 2015. J Neurophysiol. 114: 159-69. PMID: 25904713
  5. An astrocyte-dependent mechanism for neuronal rhythmogenesis.  |  Morquette, P., et al. 2015. Nat Neurosci. 18: 844-54. PMID: 25938883
  6. Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles.  |  Mishra, A., et al. 2016. Nat Neurosci. 19: 1619-1627. PMID: 27775719
  7. Transmitter release at frog end-plate loaded with a Ca2+-chelator, BAPTA: hypertonicity and erythrosin B augment the release independently of internal Ca2+.  |  Tanabe, N. and Kijima, H. 1988. Neurosci Lett. 92: 52-7. PMID: 2847089
  8. Fluorescent Ca2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions.  |  Smith, NA., et al. 2018. Sci Signal. 11: PMID: 29382785
  9. Monitoring intracellular nanomolar calcium using fluorescence lifetime imaging.  |  Zheng, K., et al. 2018. Nat Protoc. 13: 581-597. PMID: 29470463
  10. Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells.  |  Matos, M., et al. 2018. Nat Commun. 9: 4254. PMID: 30315174
  11. Calcium-independent increase of transmitter release at frog end-plate by trinitrobenzene sulphonic acid.  |  Kijima, H. and Tanabe, N. 1988. J Physiol. 403: 135-49. PMID: 3150982
  12. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.  |  Tsien, RY. 1980. Biochemistry. 19: 2396-404. PMID: 6770893
  13. Properties of neuroprotective cell-permeant Ca2+ chelators: effects on [Ca2+]i and glutamate neurotoxicity in vitro.  |  Tymianski, M., et al. 1994. J Neurophysiol. 72: 1973-92. PMID: 7823112
  14. Chelation of intracellular Ca2+ inhibits murine keratinocyte differentiation in vitro.  |  Li, L., et al. 1995. J Cell Physiol. 163: 105-14. PMID: 7896886
  15. Involvement of pre- and postsynaptic mechanisms in posttetanic potentiation at Aplysia synapses.  |  Bao, JX., et al. 1997. Science. 275: 969-73. PMID: 9020078

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

BAPTA tetrapotassium salt, 100 mg

sc-202076A
100 mg
$114.00

BAPTA tetrapotassium salt, 1 g

sc-202076
1 g
$227.00

What is the osmole for a 1 mole K4BAPTA? Thanks,

Asked by: Sol2
Thank you for your question. It would be helpful if you could call us directly at 800-457-3801 ext 1, allowing for a more interactive discussion of this and other related questions.
Answered by: Blake J
Date published: 2021-08-11
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Rated 5 out of 5 by from Heim et alHeim et al. (PubMed ID 14742421) used BAPTA tetrapotassium salt to obtain dissociation kinetics of E. coli via in vitro spectroscopy. -SCBT Publication Review
Date published: 2015-02-02
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BAPTA tetrapotassium salt is rated 5.0 out of 5 by 1.
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