BAP31 Antibody (6D148): sc-70401
- BAP31 Antibody (6D148) is a rat monoclonal IgG2a provided at 200 µg/ml
- epitope mapping at amino acids 230-246 of BAP31 of human origin
- recommended for detection of BAP31 of mouse, rat and human origin by WB, IP and IF; also reactive with additional species, including bovine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BAP31 Antibody (6D148). This work is in progress.
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BAP31 Antibody (6D148) is a rat monoclonal IgG2a antibody that detects BAP31 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). BAP31 is a crucial integral membrane protein located in the endoplasmic reticulum, where BAP31 plays a significant role in apoptosis regulation by forming a protein complex that links initiator caspases, like procaspase-8, with anti-apoptotic proteins such as Bcl-2 and Bcl-XL. This interaction is vital for the apoptotic signaling pathway, as BAP31′s cytosolic domain contains two caspase recognition sites that are cleaved by initiator caspases, leading to the generation of a p20 fragment during apoptosis. This fragment remains embedded in the membrane and acts as a potent inducer of cell death when ectopically expressed. BAP31 cleavage is essential for the execution of cytoplasmic apoptotic events, including membrane fragmentation, and facilitates the communication between mitochondria and the endoplasmic reticulum during Fas-mediated apoptosis. BAP31 is ubiquitously expressed across murine tissues and is located on the X chromosome in both mice and humans, highlighting BAP31′s importance in various biological processes and potential implications in disease states. Anti-BAP31 antibody (6D148) is an invaluable tool for researchers studying apoptosis and related signaling pathways.
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BAP31 Antibody (6D148) References:
- Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria. | Wang, B., et al. 2003. J Biol Chem. 278: 14461-8. PMID: 12529377
- BAP31 and its caspase cleavage product regulate cell surface expression of tetraspanins and integrin-mediated cell survival. | Stojanovic, M., et al. 2005. J Biol Chem. 280: 30018-24. PMID: 15946936
- BAP31 is involved in the retention of cytochrome P450 2C2 in the endoplasmic reticulum. | Szczesna-Skorupa, E. and Kemper, B. 2006. J Biol Chem. 281: 4142-8. PMID: 16332681
- BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex. | Wang, B., et al. 2008. Cell. 133: 1080-92. PMID: 18555783
- CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress. | Namba, T., et al. 2013. Cell Rep. 5: 331-9. PMID: 24139803
- Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein. | Li, Y., et al. 2015. Virology. 482: 105-10. PMID: 25854864
- BAP31, a promising target for the immunotherapy of malignant melanomas. | Yu, S., et al. 2015. J Exp Clin Cancer Res. 34: 36. PMID: 25903101
- BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites. | Namba, T. 2019. Sci Adv. 5: eaaw1386. PMID: 31206022
- MiR-362 suppresses cervical cancer progression via directly targeting BAP31 and activating TGFβ/Smad pathway. | Yang, S., et al. 2021. Cancer Med. 10: 305-316. PMID: 33210473
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAP31 Antibody (6D148) | sc-70401 | 200 µg/ml | $322.00 |