BANP Antibody (1524CT337.6.32): sc-517314
- BANP Antibody (1524CT337.6.32) is a mouse monoclonal IgG1 κ BANP antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 30-390 of BANP of human origin
- recommended for detection of BANP of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BANP Antibody (1524CT337.6.32). This work is in progress.
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BANP Antibody (1524CT337.6.32) is a mouse monoclonal IgG1 kappa light chain antibody that detects BANP protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-BANP antibody (1524CT337.6.32) is available as a non-conjugated format. BANP, also known as BTG3 associated nuclear protein, BEND1, SMARBP1, or SMAR1, is a crucial 519 amino acid protein that resides in the nucleus and is a member of the BANP/SMAR1 family. BANP plays a significant role in regulating V(D)J recombination during T-cell development by interacting with key proteins such as CDP and p53. Specifically, BANP binds to a scaffold/matrix DNA attachment region, which is essential for repressing the enhancer function of the T-cell receptor beta (TCRβ). Furthermore, BANP is involved in promoting the phosphorylation of p53 at serine residues, leading to the nuclear accumulation of p53 and subsequent cell cycle arrest, highlighting BANP′s importance in cellular regulation and tumor suppression. Notably, BANP expression is downregulated in breast cancer cells, suggesting a potential role as a tumor suppressor. Additionally, three isoforms of BANP arise from alternative splicing events, which may contribute to diverse functional roles in cellular processes.
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BANP Antibody (1524CT337.6.32) References:
- Identification and molecular analysis of BANP. | Birot, A., et al. 2000. Gene. 253: 189-96. PMID: 10940556
- SMAR1, a novel, alternatively spliced gene product, binds the Scaffold/Matrix-associated region at the T cell receptor beta locus. | Chattopadhyay, S., et al. 2000. Genomics. 68: 93-6. PMID: 10950932
- Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice. | Kaul, R., et al. 2003. Int J Cancer. 103: 606-15. PMID: 12494467
- SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRbeta enhancer (Ebeta). | Kaul-Ghanekar, R., et al. 2004. Nucleic Acids Res. 32: 4862-75. PMID: 15371550
- Abnormal V(D)J recombination of T cell receptor beta locus in SMAR1 transgenic mice. | Kaul-Ghanekar, R., et al. 2005. J Biol Chem. 280: 9450-9. PMID: 15623522
- Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif. | Jalota, A., et al. 2005. J Biol Chem. 280: 16019-29. PMID: 15701641
- Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex. | Rampalli, S., et al. 2005. Mol Cell Biol. 25: 8415-29. PMID: 16166625
- Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions. | Singh, K., et al. 2009. J Biol Chem. 284: 1267-78. PMID: 18981184
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BANP Antibody (1524CT337.6.32) | sc-517314 | 100 µg/ml | $316.00 |