Molecular structure of BAN ORL 24, CAS Number: 475150-69-7
BAN ORL 24 (CAS 475150-69-7)
Alternate Names:
(2R)-1-(Phenylmethyl)-N-[3-(spiro[i sobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide
Application:
BAN ORL 24 is a KOR-3 (NOP) antagonist
CAS Number:
475150-69-7
Purity:
≥98%
Molecular Weight:
506.51
Molecular Formula:
C27H35N3O2.2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Potent and selective NOP receptor antagonist (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). Inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca2+ mobilization in CHO cells in vitro and antagonizes NOP agonist-induced reduction in locomotor activity in vivo. Brain penetrant.
BAN ORL 24 (CAS 475150-69-7) References
Goto et al (2006) Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity. J.Med.Chem. 49 847. Liao et al (2009) 1-Benzyl-N-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices. Eur.J.Pharmacol. 606 84. Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50.Inhibitor of:
KOR-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAN ORL 24, 10 mg | sc-291924 | 10 mg | $185.00 | |||
BAN ORL 24, 50 mg | sc-291924A | 50 mg | $793.00 |