BAMBI Antibody (3B7): sc-100681

BAMBI Antibody (3B7) is a mouse monoclonal IgG1 kappa light chain antibody that detects BAMBI protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-BAMBI antibody (3B7) is available as the non-conjugated format. BAMBI, or BMP and activin membrane-bound inhibitor homolog, NMA, is a membrane-spanning glycoprotein that plays a crucial role as a negative regulator of TGF-beta signaling during development, which is vital for maintaining cellular homeostasis and regulating various developmental processes. Notably, BAMBI is structurally related to the type I TGF-beta receptor family; however, BAMBI functions as a pseudoreceptor due to the absence of an intracellular serine/threonine kinase domain, which limits signal transduction ability. The regulation of BAMBI transcription is influenced by key signaling molecules such as beta-catenin, BMP, Smad3, and Smad4, highlighting integration into complex signaling networks. BAMBI expression is notably elevated in colorectal and hepatocellular carcinomas compared to non-cancerous tissues, suggesting a potential role in tumor biology. During odontogenesis, BAMBI is expressed at high levels, and BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis, indicating importance in developmental biology. BAMBI can be detected in poorly metastatic human melanoma cell lines, further emphasizing relevance in cancer research.

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BAMBI Antibody (3B7) References:

1. Bambi is coexpressed with Bmp-4 during mouse embryogenesis.  |  Grotewold, L., et al. 2001. Mech Dev. 100: 327-30. PMID: 11165491
2. Cloning, characterization, and tissue expression pattern of mouse Nma/BAMBI during odontogenesis.  |  Knight, C., et al. 2001. J Dent Res. 80: 1895-902. PMID: 11706948
3. Expression of Bambi is widespread in juvenile and adult rat tissues and is regulated in male germ cells.  |  Loveland, KL., et al. 2003. Endocrinology. 144: 4180-6. PMID: 12933693
4. Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells.  |  Sekiya, T., et al. 2004. J Biol Chem. 279: 6840-6. PMID: 14660579
5. Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling.  |  Sekiya, T., et al. 2004. Biochem Biophys Res Commun. 320: 680-4. PMID: 15240101
6. A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways.  |  Zuzarte-Luís, V., et al. 2004. Dev Biol. 272: 39-52. PMID: 15242789
7. BAMBI is expressed in endothelial cells and is regulated by lysosomal/autolysosomal degradation.  |  Xavier, S., et al. 2010. PLoS One. 5: e12995. PMID: 20886049
8. BAMBI regulates angiogenesis and endothelial homeostasis through modulation of alternative TGFβ signaling.  |  Guillot, N., et al. 2012. PLoS One. 7: e39406. PMID: 22761782
9. BAMBI promotes macrophage proliferation and differentiation in gliomas.  |  Wang, D., et al. 2018. Mol Med Rep. 17: 3960-3966. PMID: 29286116
10. Hypoxia-responsive PPARGC1A/BAMBI/ACSL5 axis promotes progression and resistance to lenvatinib in hepatocellular carcinoma.  |  Zhang, Q., et al. 2023. Oncogene. 42: 1509-1523. PMID: 36932115
11. Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance.  |  Wang, L., et al. 2023. J Clin Invest. 133: PMID: 38099498
12. [On the significiance of mast cells in the calcification of tissues during calciphylaxis].  |  Polushkin, BV. 1968. Arkh Patol. 30: 45-9. PMID: 5734148

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BAMBI Antibody (3B7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-BAMBI Antibody (3B7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BAMBI Antibody (3B7) Specifications

Alternate Product Name: BAMBI

Product Clone Name: 3B7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-261

Epitope Target: BAMBI

Epitope Species: human

Product Reactivity/Detection: BAMBI

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for BAMBI Antibody (3B7): N/A