Bakuchiol is an antioxidant inhibitor of protein tyrosine phosphatase 1B (PTP1B). It also acts as an inhibitor of mitochondrial lipid peroxidation and inducible nitric oxide synthase (iNOS; NOS II) expression. Bakuchiol is also a DNA polymerase inhibitor which shows antimicrobial and cytotoxic activity.
1. Pae, H.O. et al. 2001. Int. Immunopharmacol. 1(9-10): 1849-1855. PMID: 11562076 2. Backhouse, C.N. et al. 2001. J Ethnopharmacol. 78(1): 27-31. PMID: 11585684 3. Haraguchi, H. et al. 2002. Phytother Res. 16(6): 539-544. PMID: 12237811 4. Adhikari, S. et al. 2003. Chem. Res. Toxicol. 16(9): 1062-1069. PMID: 12971793 5. Bapat, K. et al. 2005. Appl Radiat Isot. 62(3): 389-393. PMID: 15607914 6. Kim, Y.C. et al. 2005. Planta Med. 71(1): 87-89. PMID: 15678382 7. Park, E.J. et al. 2005. Planta Med. 71(6): 508-513. PMID: 15971120 8. Park, E.J. et al. 2007. Eur. J. Pharmacol. 559(2-3): 115-123. PMID: 17292878
I am a natural skin care formulator and I am interested in adding Bakuchiol to a prod. What percentage of Bakuchios recommended to be effective in an oil based product? Any info on how to use this ingredient in natural skin care is appreciated.
Asked by: alysha
Products are provided for research or laboratory use only (RUO) and are not to be administered to humans or used for medical diagnostics.
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Park et alPark et al. (PubMed ID 17292878) found that bakuchiol reduced activated hepatic stellate cells of rats recovering from liver injury by inducing apoptosis via activation of caspase 3. -SCBT Publication Review
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