Bag-5 Antibody (18Z): sc-101215
- Bag-5 Antibody (18Z) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant Bag-5 of human origin
- recommended for detection of Bag-5 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bag-5 Antibody (18Z). This work is in progress.
Bag-5 Antibody (18Z) is a mouse monoclonal IgG1 antibody that detects Bag-5 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Bag-5, also known as Bcl-2-associated athanogene 5 or Bag family molecular chaperone regulator 5, is a crucial member of the Bag family of proteins, characterized by four Bag domains. Anti-Bag-5 antibody (18Z) plays a significant role in studying cellular stress responses by binding with high affinity to the HSC 70/HSP 70 ATPase domain, thereby regulating chaperone activity and apoptosis. Notably, Bag-5 is a key component of the HSP 70/Parkin complex, where Bag-5 inhibits the E3 ubiquitin ligase activity of Parkin and modulates HSP 70 chaperone activity. The interaction between Bag-5 and the ATPase domain of HSP 70, as well as the N-terminal linker region of Parkin, is vital for maintaining cellular homeostasis, particularly in the context of dopaminergic neuron injury. Upon such injury, Bag-5 expression is upregulated, sensitizing neurons to cell death, which underscores Bag-5′s potential as a therapeutic target in neurodegenerative diseases like Parkinson′s disease, where mutations in the Parkin gene are implicated. Bag-5 monoclonal antibody (18Z) is an invaluable tool for researchers investigating the molecular mechanisms underlying these critical cellular processes.
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Bag-5 Antibody (18Z) References:
- A comparison of three neonatal resuscitation devices. | Bennett, S., et al. 2005. Resuscitation. 67: 113-8. PMID: 16081202
- Nursing interventions to reduce the risk of catheter-associated urinary tract infection: part 2: staff education, monitoring, and care techniques. | Willson, M., et al. 2009. J Wound Ostomy Continence Nurs. 36: 137-54. PMID: 19287262
- CA125--a test with a change of heart. | Sikaris, KA. 2011. Heart Lung Circ. 20: 634-40. PMID: 20822954
- [BAG family gene and its relationship with lung adenocarcinoma susceptibility]. | Li, Y., et al. 2010. Zhongguo Fei Ai Za Zhi. 13: 942-6. PMID: 20959066
- Injectable radiopaque and bioactive polycaprolactone-ceramic composites for orthopedic augmentation. | No, YJ., et al. 2015. J Biomed Mater Res B Appl Biomater. 103: 1465-77. PMID: 25449121
- Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation. | Hakui, H., et al. 2022. Sci Transl Med. 14: eabf3274. PMID: 35044787
- ALK-rearranged renal cell carcinoma with TPM3::ALK gene fusion and review of the literature. | Galea, LA., et al. 2023. Virchows Arch. 482: 625-633. PMID: 36370168
- Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch. | Bracho-Valdés, I., et al. 2023. Int J Mol Sci. 24: PMID: 38139359
- BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly. | Gan, S., et al. 2024. EMBO Rep. 25: 2045-2070. PMID: 38454159
- An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. | Takayama, S., et al. 1999. J Biol Chem. 274: 781-6. PMID: 9873016
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bag-5 Antibody (18Z) | sc-101215 | 100 µg/ml | $333.00 |