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Bafilomycin B1® is an inhibitor of vacuolar-ATPase enzymes in fungi. MF: C44H65NO13, MW: 815.99. Cited in 2 publications">
Bafilomycin B1, a plecomacrolide originally found to be produced by different Streptomyces species, has been shown to display activity against gram-positive bacteria and fungi. This compound is shown to be a potent and selective inhibitor of all V-ATPases. Studies have demonstrated that Bafilomycin B1 inhibits the osteoclastic proton pump in vitro. In addition, this compound has displayed a capacity to have concentration-dependent effects on neuronal cell viability. Bafilomycin B1 may also promote the accumulation of autophagic vacuoles and trigger Bax-dependent apoptosis.
1. Werner, G., et al. 1984. J. Antibiot. 37: 110-117. PMID: 6423597
2. Dröse, S., et al. 1997. J. Exp. Biol. 200: 1-8. PMID: 9023991
3. Farina, C. and Gagliardi, S. 2002. Curr. Pharm. Des. 8: 2033-2048. PMID: 12171517
4. Shacka, J.J., et al. 2006. Autophagy. 2: 228-230. PMID: 16874105
See how others have used Bafilomycin B1. Click on the entry to view the PubMed entry .
PMID: # 26230309 Cioffi, AG. et al. 2015. J. Am. Chem. Soc. 137: 10096-9.
PMID: # 23663353 Hwang, JY. et al. 2013. AMB Express. 3: 24.
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