BAF53 Antibody (G-2): sc-137081
- BAF53 Antibody (G-2) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 87-129 near the N-terminus of BAF53 of human origin
- recommended for detection of BAF53 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine, bovine and porcine
- TransCruz reagent for ChIP application (sc-137081 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BAF53 Antibody (G-2) for WB and IHC(P) applications. These reagents are now offered in bundles with BAF53 Antibody (G-2) (see ordering information below).
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BAF53 Antibody (G-2) is a mouse monoclonal IgG2a antibody that detects BAF53 protein of mouse, rat, and human origin through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). BAF53, a crucial component of the SWI/SNF chromatin remodeling complex, plays a significant role in regulating gene expression by facilitating ATP-dependent alterations in chromatin structure. BAF53 is primarily located in both the nucleus and cytoplasm, which is vital for shuttling between these compartments and participating in various cellular processes. BAF53′s interaction with other proteins, such as TIP49 and TIP48, is essential for mediating c-Myc oncogenic activity, highlighting BAF53′s importance in cellular growth and proliferation. Additionally, BAF53 contains a conserved N-terminal motif with specific residues at serine 2 and tyrosine 6 that are critical for activity, underscoring the intricate regulatory mechanisms that govern BAF53′s function in chromatin remodeling and gene expression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BAF53 Antibody (G-2) References:
- Expression of SMARCF1, a truncated form of SWI1, in neuroblastoma. | Takeuchi, T., et al. 2001. Am J Pathol. 158: 663-72. PMID: 11159203
- Alternative splicing products of the gene for a human nuclear actin-related protein, hArpNbeta/Baf53, that encode a protein isoform, hArpNbetaS, in the cytoplasm. | Ohfuchi, E., et al. 2002. Biosci Biotechnol Biochem. 66: 1740-3. PMID: 12353638
- The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP. | Oma, Y., et al. 2003. Biochem Biophys Res Commun. 301: 521-8. PMID: 12565893
- Cytoplasmic localization and nucleo-cytoplasmic shuttling of BAF53, a component of chromatin-modifying complexes. | Lee, JH., et al. 2003. Mol Cells. 16: 78-83. PMID: 14503849
- BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere. | Minoda, A., et al. 2005. Mol Biol Cell. 16: 316-27. PMID: 15483052
- Expansion of chromosome territories with chromatin decompaction in BAF53-depleted interphase cells. | Lee, K., et al. 2007. Mol Biol Cell. 18: 4013-23. PMID: 17652455
- Varying modulation of HIV-1 LTR activity by Baf complexes. | Van Duyne, R., et al. 2011. J Mol Biol. 411: 581-96. PMID: 21699904
- The Actin-Related Protein BAF53 Is Essential for Chromosomal Subdomain Integrity. | Lee, K., et al. 2015. Mol Cells. 38: 789-95. PMID: 26242195
- Repeated social defeat in male mice induced unique RNA profiles in projection neurons from the amygdala to the hippocampus. | Biltz, RG., et al. 2025. Brain Behav Immun Health. 43: 100908. PMID: 39720627
- Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. | Zhao, K., et al. 1998. Cell. 95: 625-36. PMID: 9845365
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAF53 Antibody (G-2) | sc-137081 | 200 µg/ml | $322.00 | |||
BAF53 Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-537399 | 200 µg Ab; 10 µg BP | $361.00 | |||
BAF53 Antibody (G-2): m-IgGκ BP-HRP Bundle | sc-534653 | 200 µg Ab; 40 µg BP | $361.00 | |||
BAF53 Antibody (G-2): m-IgG2a BP-HRP Bundle | sc-548006 | 200 µg Ab; 10 µg BP | $361.00 | |||
BAF53 (G-2) Neutralizing Peptide | sc-137081 P | 100 µg/0.5 ml | $69.00 | |||
BAF53 Antibody (G-2) X | sc-137081 X | 200 µg/0.1 ml | $322.00 |