Date published: 2026-4-5

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Bacimethrin (CAS 3690-12-8)

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Application:
Bacimethrin is An antibacterial agent and thiamine antagonist
CAS Number:
3690-12-8
Purity:
≥98%
Molecular Weight:
155.2
Molecular Formula:
C6H9N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Protocatechuic acid ethyl ester, a derivative of protocatechuic acid, exhibits promising bioactivity and has garnered attention in scientific research for its diverse potential applications. This compound is recognized for its antioxidant properties, attributed to its ability to scavenge free radicals and inhibit oxidative stress-induced damage. In addition to its antioxidant effects, protocatechuic acid ethyl ester has demonstrated anti-inflammatory activity by modulating inflammatory mediators and pathways, suggesting its potential utility in inflammatory conditions. Moreover, research has revealed its neuroprotective properties, with studies highlighting its ability to mitigate neuronal damage and enhance cognitive function in experimental models of neurodegenerative diseases. Furthermore, protocatechuic acid ethyl ester has shown antimicrobial activity against various pathogens, including bacteria and fungi, indicating its potential as a natural antimicrobial agent. Its multifaceted bioactivity underscores its significance in biomedical research, where it is investigated for its potential in oxidative stress-related disorders, inflammation-driven pathologies, neurodegenerative diseases, and infectious conditions. Additionally, ongoing studies explore its pharmacokinetics, metabolism, and safety profile to further explain its applicability and optimize its development as a potential agent or dietary supplement.


Bacimethrin (CAS 3690-12-8) References

  1. Action of the thiamine antagonist bacimethrin on thiamine biosynthesis.  |  Zilles, JL., et al. 2000. J Bacteriol. 182: 5606-10. PMID: 10986269
  2. The mechanism of action of bacimethrin, a naturally occurring thiamin antimetabolite.  |  Reddick, JJ., et al. 2001. Bioorg Med Chem Lett. 11: 2245-8. PMID: 11527707
  3. A genetic screen for the identification of thiamin metabolic genes.  |  Lawhorn, BG., et al. 2004. J Biol Chem. 279: 43555-9. PMID: 15292217
  4. Reversal of the substrate specificity of CMP N-glycosidase to dCMP.  |  Sikowitz, MD., et al. 2013. Biochemistry. 52: 4037-47. PMID: 23659472
  5. Biosynthesis of a thiamin antivitamin in Clostridium botulinum.  |  Cooper, LE., et al. 2014. Biochemistry. 53: 2215-7. PMID: 24654570
  6. Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry.  |  Zhao, G., et al. 2014. Nucleic Acids Res. 42: 8115-24. PMID: 24920828
  7. Competence of Thiamin Diphosphate-Dependent Enzymes with 2'-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin.  |  Nemeria, NS., et al. 2016. Biochemistry. 55: 1135-48. PMID: 26813608
  8. A strictly monofunctional bacterial hydroxymethylpyrimidine phosphate kinase precludes damaging errors in thiamin biosynthesis.  |  Thamm, AM., et al. 2017. Biochem J. 474: 2887-2895. PMID: 28729425
  9. Genomic insights into the thiamin metabolism of Paenibacillus thiaminolyticus NRRL B-4156 and P. apiarius NRRL B-23460.  |  Sannino, D. and Angert, ER. 2017. Stand Genomic Sci. 12: 59. PMID: 29026451
  10. Metabolic products of microorganisms. 239. Bacimethrin isolated from Streptomyces albus identification, derivatives, synthesis and biological properties.  |  Drautz, H., et al. 1987. J Antibiot (Tokyo). 40: 1431-9. PMID: 3680009

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Bacimethrin, 500 µg

sc-364104
500 µg
$173.00

Bacimethrin, 1 mg

sc-364104A
1 mg
$306.00