B7-1 Antibody (3H5): sc-58911

B7-1 Antibody (3H5) is a mouse monoclonal IgG1 antibody that detects B7-1 in mouse and rat samples through immunoprecipitation (IP) and flow cytometry (FCM) applications. B7-1, also known as CD80, plays a crucial role in the immune response by providing essential costimulatory signals necessary for T cell activation and proliferation. B7-1 is primarily located on the surface of antigen-presenting cells, where B7-1 interacts with T cell receptors CD28 and CTLA-4, thereby influencing T cell responses. B7-1′s location in the immune system is fundamental, as B7-1 expression on antigen-presenting cells is vital for the initiation and regulation of adaptive immunity. Through binding to CD28, B7-1 enhances T cell activation, while B7-1 interaction with CTLA-4 serves as a negative regulatory signal, ensuring that T cell responses are appropriately modulated to prevent overactivation and autoimmunity. The balance between these interactions is critical for maintaining immune homeostasis, making B7-1 a significant target for therapeutic interventions in various immune-related conditions. Anti-B7-1 antibody (3H5) is an invaluable tool for researchers studying T cell activation and the intricate signaling pathways involved in immune responses.

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B7-1 Antibody (3H5) References:

1. B7-1 and B7-2: similar costimulatory ligands with different biochemical, oligomeric and signaling properties.  |  Bhatia, S., et al. 2006. Immunol Lett. 104: 70-5. PMID: 16413062
2. B7-1 Is Not Induced in Podocytes of Human and Experimental Diabetic Nephropathy.  |  Gagliardini, E., et al. 2016. J Am Soc Nephrol. 27: 999-1005. PMID: 26319246
3. CTLA4-Ig in B7-1-positive diabetic and non-diabetic kidney disease.  |  Bassi, R., et al. 2016. Diabetologia. 59: 21-29. PMID: 26409459
4. PD-L1 Binds to B7-1 Only In Cis on the Same Cell Surface.  |  Chaudhri, A., et al. 2018. Cancer Immunol Res. 6: 921-929. PMID: 29871885
5. The role of B7-1 in proteinuria of glomerular origin.  |  Novelli, R., et al. 2018. Nat Rev Nephrol. 14: 589-596. PMID: 29959373
6. Targeting B7-1 in immunotherapy.  |  Chen, R., et al. 2020. Med Res Rev. 40: 654-682. PMID: 31448437
7. Peptide Blocking CTLA-4 and B7-1 Interaction.  |  Podlesnykh, SV., et al. 2021. Molecules. 26: PMID: 33419027
8. B7-1 mediates podocyte injury and glomerulosclerosis through communication with Hsp90ab1-LRP5-β-catenin pathway.  |  Li, J., et al. 2022. Cell Death Differ. 29: 2399-2416. PMID: 35710882
9. Glomerular B7-1 staining: toward precision medicine for treatment of recurrent focal segmental glomerulosclerosis.  |  Wang, CS., et al. 2023. Pediatr Nephrol. 38: 13-15. PMID: 35725967
10. Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor.  |  Morano, NC., et al. 2022. J Clin Invest. 132: PMID: 36107635

The preferred B7-1 antibody is B7-1 Antibody (F-7): sc-376012.