B2 (CAS 115687-05-3)
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B2, also known as 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline. This compound is recognized for its role as a cell-permeable inhibitor of SIRT2 (sirtuin 2), a deacetylase enzyme implicated in various cellular functions including apoptosis, inflammation, and stress resistance through the regulation of protein acetylation. The compound′s ability to inhibit SIRT2 is particularly useful for studying protein regulation mechanisms at a molecular level, providing insights into cellular processes such as aging and protein function regulation. The specific activity of B2 in promoting inclusion formation in cellular models highlights its utility in biochemical research, focusing on the cellular pathways affected by protein aggregations, which can influence various cellular outcomes. This chemical′s relevance in basic scientific research extends to its potential to explain the pathways through which cellular regulation and protein interaction networks are modulated.
B2 (CAS 115687-05-3) References
- Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. | Bodner, RA., et al. 2006. Proc Natl Acad Sci U S A. 103: 4246-51. PMID: 16537516
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
B2, 500 µg | sc-202486 | 500 µg | $80.00 | |||
B2, 5 mg | sc-202486A | 5 mg | $160.00 | |||
B2, 25 mg | sc-202486B | 25 mg | $700.00 |