Molecular structure of B-HT 920, CAS Number: 36085-73-1
B-HT 920 (CAS 36085-73-1)
Alternate Names:
Talipexole; 5,6,7,8-Tetrahydro-6-(2-propen-1-yl)-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride
Application:
B-HT 920 is a dopamine D2 receptor agonist, SR-3 antagonist and α2-adrenoceptor agonist
CAS Number:
36085-73-1
Purity:
≥99%
Molecular Weight:
282.23
Molecular Formula:
C10H15N3S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
B-HT 920 is a D2DR (dopamine D2 receptor) agonist, SR-3 antagonist and AR (α2-adrenoceptor) agonist. B-HT 920 also displays antiparkinsonian activity.
B-HT 920 (CAS 36085-73-1) References
- Suppressive effect of the dopamine D2 receptor agonist B-HT 920 on rat grooming. | Ferrari, F., et al. 1992. Eur J Pharmacol. 216: 345-50. PMID: 1358627
- Dopamine receptor mediated hypothermic action of B-HT 920 in rats. | Verma, A. and Kulkarni, SK. 1991. J Pharm Pharmacol. 43: 421-4. PMID: 1681056
- Potentiation of yawning responses to the dopamine receptor agonists B-HT 920 and SND 919 by pindolol in the rat. | Yamada, K., et al. 1990. J Neural Transm Gen Sect. 79: 19-24. PMID: 1967531
- Stimulation of D1 dopamine receptors reveals direct effects of the preferential dopamine autoreceptor agonist B-HT 920 on postsynaptic dopamine receptors. | Andén, NE. and Grabowska-Andén, M. 1988. Acta Physiol Scand. 134: 285-90. PMID: 2852446
- B-HT 920 and B-HT 958: presynaptic effects on electrically evoked 3H-dopamine release from slices of rat nucleus accumbens. | Cichini, G., et al. 1987. Naunyn Schmiedebergs Arch Pharmacol. 335: 28-31. PMID: 2883584
- Inhibitory role of D-1 dopamine receptors for the jerks induced by B-HT 920 in rats. | Grabowska-Andén, M. and Andén, NE. 1987. J Pharm Pharmacol. 39: 660-1. PMID: 2888862
- B-HT 920 stimulates postsynaptic D2 dopamine receptors in the normal rat: electrophysiological and behavioral evidence. | Johansen, PA., et al. 1988. Life Sci. 43: 515-24. PMID: 2900459
- The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment. | Hinzen, D., et al. 1986. Eur J Pharmacol. 131: 75-86. PMID: 3816949
- The putative dopamine autoreceptor agonist B-HT 920 decreases nigral dopamine cell firing rate and prolactin release in rat. | Eriksson, E., et al. 1985. Life Sci. 36: 1819-27. PMID: 3990512
- In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release. | Robertson, GS., et al. 1993. J Pharmacol Exp Ther. 264: 1344-51. PMID: 8095550
- B-HT 920, a dopamine D2 agonist, in the treatment of negative symptoms of chronic schizophrenia. | Ohmori, T., et al. 1993. Biol Psychiatry. 33: 687-93. PMID: 8102551
- 5-HT3 receptor blocking properties of the antiparkinsonian agent, talipexole. | Nishio, H., et al. 1996. Gen Pharmacol. 27: 779-85. PMID: 8842679
- Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated rats. | Ricci, D. and Taira, CA. 1999. Gen Pharmacol. 32: 29-34. PMID: 9888250
Inhibitor of:
SR.Activator of:
AR, and D2DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
B-HT 920, 10 mg | sc-203523 | 10 mg | $142.00 | |||
B-HT 920, 50 mg | sc-203523A | 50 mg | $583.00 |