Molecular structure of Azoxymethane, CAS Number: 25843-45-2
Azoxymethane (CAS 25843-45-2)
See product citations (8)
Alternate Names:
Azoxymethane is also known as AOM.
Application:
Azoxymethane is a potent alkylating agent commonly used in research to study DNA methylation processes and the mechanisms of chemical-induced mutagenesis.
CAS Number:
25843-45-2
Purity:
≥93%
Molecular Weight:
74.08
Molecular Formula:
C2H6N2O
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Azoxymethane (CAS: 25843-45-2) is a potent chemical compound widely utilized in experimental and mechanistic research to investigate the biochemical pathways of alkylating agents. It is particularly valuable in studies exploring DNA methylation, mutagenesis, and cellular responses to genotoxic stress. Owing to its well-characterized molecular structure and reactivity, azoxymethane serves as a model compound for elucidating the mechanisms of oxidative metabolism, enzyme-mediated activation, and DNA adduct formation. It is also employed in analytical method development, stability testing, and chemical reactivity profiling, making it a critical tool for toxicology, molecular biology, and chemical safety research.
Azoxymethane (CAS 25843-45-2) References
- Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats. | Wali, RK., et al. 1999. Carcinogenesis. 20: 2355-60. PMID: 10590233
- Anatomical site-specific response to DNA damage is related to later tumor development in the rat azoxymethane colon carcinogenesis model. | Hong, MY., et al. 2001. Carcinogenesis. 22: 1831-5. PMID: 11698346
- Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. | Takahashi, M. and Wakabayashi, K. 2004. Cancer Sci. 95: 475-80. PMID: 15182426
- Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention. | Reddy, BS. 2004. Environ Mol Mutagen. 44: 26-35. PMID: 15199544
- Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice. | Suzuki, R., et al. 2006. Carcinogenesis. 27: 162-9. PMID: 16081511
- Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet. | Bissahoyo, A., et al. 2005. Toxicol Sci. 88: 340-5. PMID: 16150884
- Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet. | Reddy, BS., et al. 1990. Cancer Res. 50: 2562-8. PMID: 2109653
- Inhibitory effect of dietary p-methoxybenzeneselenol on azoxymethane-induced colon and kidney carcinogenesis in female F344 rats. | Reddy, BS., et al. 1985. J Natl Cancer Inst. 74: 1325-8. PMID: 2987595
- Inhibition of intestinal carcinogenesis in rats: effect of difluoromethylornithine with piroxicam or fish oil. | Nigro, ND., et al. 1986. J Natl Cancer Inst. 77: 1309-13. PMID: 3099048
- Effect of voluntary exercise on azoxymethane-induced colon carcinogenesis in male F344 rats. | Reddy, BS., et al. 1988. Cancer Res. 48: 7079-81. PMID: 3191484
- Direct examination of the clonality of carcinogen-induced colonic epithelial dysplasia in chimeric mice. | Ponder, BA. and Wilkinson, MM. 1986. J Natl Cancer Inst. 77: 967-76. PMID: 3463823
- Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development. | Reddy, BS., et al. 1987. Cancer Res. 47: 5340-6. PMID: 3652039
- Effects of carcinogen dosage on experimental colonic carcinogenesis by azoxymethane: an ultrastructural study of grossly normal colonic mucosa. | Pan, Q., et al. 1985. J Natl Cancer Inst. 74: 689-98. PMID: 3856071
- Effect of different levels of dietary trans fat or corn oil on azoxymethane-induced colon carcinogenesis in F344 rats. | Reddy, BS., et al. 1985. J Natl Cancer Inst. 75: 791-8. PMID: 3862909
- Effect of neomycin on azoxymethane-induced colon carcinogenesis in F344 rats. | Reddy, BS., et al. 1984. J Natl Cancer Inst. 73: 275-9. PMID: 6588232
- Large intestinal carcinogenesis. II. Histogenesis and unusual features of low-dose azoxymethane-induced carcinomas in F344 rats. | Shamsuddin, AM. and Hogan, ML. 1984. J Natl Cancer Inst. 73: 1297-305. PMID: 6595440
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Azoxymethane, 25 mg | sc-358746 | 25 mg | $466.00 | |||
Azoxymethane, 100 mg | sc-358746A | 100 mg | $1410.00 |