Date published: 2026-4-4

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Azosemide (CAS 27589-33-9)

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CAS Number:
27589-33-9
Molecular Weight:
370.84
Molecular Formula:
C12H11ClN6O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Azosemide is a compound utilized in the field of pharmacological research, where it serves as a tool to study the diuretic response and renal function. The mechanism by which azosemide exerts its effects involves the inhibition of the sodium-potassium-chloride cotransporter in the thick ascending limb of the loop of Henle. This action is of particular interest to researchers investigating the regulation of electrolyte balance and the mechanisms of fluid reabsorption in the kidney. Studies using azosemide also delve into its impact on urinary excretion patterns, offering insights into the renal handling of various ions under different physiological and experimental conditions. Additionally, the compound is used to understand the molecular basis of diuretic resistance and the adaptive responses of renal transporters to sustained diuretic action. Azosemide′s role in modulating ion transport makes it a valuable probe in the exploration of renal physiology and the pathophysiology of fluid and electrolyte disorders.


Azosemide (CAS 27589-33-9) References

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  2. Mechanism of enhanced bioavailability and diuretic effect of azosemide by ascorbic acid in rats.  |  Choi, KY., et al. 2006. Life Sci. 78: 1057-62. PMID: 16153662
  3. Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B.  |  Hampel, P., et al. 2018. Sci Rep. 8: 9877. PMID: 29959396
  4. Patients With CONgestive Heart Failure Benefit From Long-Term Treatment Effects With Novel Treatment Using Azosemide Compared With Furosemide Derived From Existing Retrospective Study Data: CONTENTED.  |  Toyoda, S., et al. 2019. J Cardiovasc Pharmacol. 73: 365-372. PMID: 31162245
  5. The search for brain-permeant NKCC1 inhibitors for the treatment of seizures: Pharmacokinetic-pharmacodynamic modelling of NKCC1 inhibition by azosemide, torasemide, and bumetanide in mouse brain.  |  Hampel, P., et al. 2021. Epilepsy Behav. 114: 107616. PMID: 33279441
  6. Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice.  |  Hampel, P., et al. 2021. Neuropharmacology. 185: 108449. PMID: 33450274
  7. The loop diuretic torasemide but not azosemide potentiates the anti-seizure and disease-modifying effects of midazolam in a rat model of birth asphyxia.  |  Welzel, B., et al. 2023. Epilepsy Behav. 139: 109057. PMID: 36586153
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Azosemide, 25 mg

sc-481492
25 mg
$174.00