Azelaic acid CAS: 123-99-9
MF: C9H16O4
MW: 188.22
An antiinflammatory compound.

Azelaic acid (CAS 123-99-9)

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Alternate Names: Nonanedioic acid; 1,7-Heptanedicarboxylic acid
Application: Azelaic acid is an antiinflammatory compound
CAS Number: 123-99-9
Molecular Weight: 188.22
Molecular Formula: C9H16O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it's anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (2.4 mg/ml at 20° C), ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol.
Storage :
Store at 4° C
Melting Point :
109-111° C (lit.)
Boiling Point :
286° C (lit.) at 100 mmHg
Density :
1.03 g/cm3
Refractive Index :
n20D 1.48 (Predicted)
pK Values :
pKa: 4.55 at 25° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
CM1980000
PubChem CID :
Merck Index :
14: 905
MDL Number :
MFCD00004432
EC Number :
204-669-1
Beilstein Registry :
1101094
SMILES :
C(CCCC(=O)O)CCCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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