Molecular structure of AZD-0156, CAS Number: 1821428-35-6
AZD-0156 (CAS 1821428-35-6)
Alternate Names:
AZD0156 AZD 0156 2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)- P5T0XWC07Z
CAS Number:
1821428-35-6
Molecular Weight:
461.60
Molecular Formula:
C26H31N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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AZD-0156 (CAS 1821428-35-6) References
- ATM in DNA repair in cancer. | Jin, MH. and Oh, DY. 2019. Pharmacol Ther. 203: 107391. PMID: 31299316
- Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination. | Nakamura, K., et al. 2021. Mol Cell. 81: 1084-1099.e6. PMID: 33450211
- ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization. | Qin, T., et al. 2022. Cell Rep. 38: 110216. PMID: 35021084
- Targeting the DNA Damage Response to Increase Anthracycline-Based Chemotherapy Cytotoxicity in T-Cell Lymphoma. | Magni, M., et al. 2022. Int J Mol Sci. 23: PMID: 35409194
- Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B cell acute lymphoblastic leukemia. | Chen, Z., et al. 2023. Sci Transl Med. 15: eabq8513. PMID: 36989375
- Genome-wide CRISPR/Cas9 library screening identified ATM signaling network genes as critical drivers for resistance to ATR inhibition in soft-tissue sarcomas: synthetic lethality and therapeutic implications. | Spalato-Ceruso, M., et al. 2023. Exp Hematol Oncol. 12: 51. PMID: 37259134
- Simultaneous Delivery of Dual Inhibitors of DNA Damage Repair Sensitizes Pancreatic Cancer Response to Irreversible Electroporation. | Long, X., et al. 2023. ACS Nano. 17: 12915-12932. PMID: 37352467
- ATM inhibition augments type I interferon response and antitumor T-cell immunity when combined with radiation therapy in murine tumor models. | Jin, WJ., et al. 2023. J Immunother Cancer. 11: PMID: 37730275
- Antioxidants and azd0156 Rescue Inflammatory Response in Autophagy-Impaired Macrophages. | Elbialy, A., et al. 2023. Int J Mol Sci. 25: PMID: 38203340
- Potentiating the radiation-induced type I interferon antitumoral immune response by ATM inhibition in pancreatic cancer. | Zhang, Q., et al. 2024. JCI Insight. 9: PMID: 38376927
Inhibitor of:
4931417G12Rik, Atm, C7orf27, C9orf119, E74 like ETS transcription factor (ELF), KIAA1370, NSE1, Rad57, and TEX38.Activator of:
CGI-99_2700060E02Rik.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AZD-0156, 10 mg | sc-507529 | 10 mg | $280.00 |