Azaspiracid-1 (CAS 214899-21-5)
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Azaspiracid-1 is a marine toxin that has garnered significant attention in the field of environmental and food safety research. It is used as a reference compound for the detection and quantification of azaspiracids in shellfish, which is for monitoring and managing the risk of shellfish poisoning. In analytical chemistry, it serves as a standard in the development of sensitive and accurate methods, such as liquid chromatography-mass spectrometry, to ensure the safety of seafood. Ecotoxicologists study Azaspiracid-1 to understand the impact of harmful algal blooms on marine ecosystems and the transfer of toxins through the food chain. Additionally, it is used in structure-activity relationship studies to elucidate the molecular basis of its toxicological effects, which aids in the understanding of how this toxin interacts with cellular targets. Researchers also investigate the biosynthesis and metabolic pathways of Azaspiracid-1-producing microorganisms to better comprehend the natural production of these compounds in the marine environment.
Azaspiracid-1 (CAS 214899-21-5) References
- Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland. | Ito, E., et al. 2000. Toxicon. 38: 917-30. PMID: 10728830
- Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets. | Román, Y., et al. 2002. Cell Signal. 14: 703-16. PMID: 12020771
- Structural revision and total synthesis of azaspiracid-1, part 1: intelligence gathering and tentative proposal. | Nicolaou, KC., et al. 2004. Angew Chem Int Ed Engl. 43: 4312-8. PMID: 15368380
- Structural revision and total synthesis of azaspiracid-1, part 2: definition of the ABCD domain and total synthesis. | Nicolaou, KC., et al. 2004. Angew Chem Int Ed Engl. 43: 4318-24. PMID: 15368381
- Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka (Oryzias latipes) embryos. | Colman, JR., et al. 2005. Toxicon. 45: 881-90. PMID: 15904683
- Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines. | Twiner, MJ., et al. 2005. Toxicon. 45: 891-900. PMID: 15904684
- Total synthesis and structural elucidation of azaspiracid-1. Construction of key building blocks for originally proposed structure. | Nicolaou, KC., et al. 2006. J Am Chem Soc. 128: 2244-57. PMID: 16478178
- Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1. | Nicolaou, KC., et al. 2006. J Am Chem Soc. 128: 2859-72. PMID: 16506764
- Azaspiracids modulate intracellular pH levels in human lymphocytes. | Alfonso, A., et al. 2006. Biochem Biophys Res Commun. 346: 1091-9. PMID: 16793022
- Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies. | Vilariño, N., et al. 2006. Chem Res Toxicol. 19: 1459-66. PMID: 17112233
- Azaspiracid-1 alters the E-cadherin pool in epithelial cells. | Ronzitti, G., et al. 2007. Toxicol Sci. 95: 427-35. PMID: 17118960
- Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study. | Vale, C., et al. 2007. J Med Chem. 50: 356-63. PMID: 17228878
- Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells. | Vilariño, N., et al. 2007. Biochem Pharmacol. 74: 327-35. PMID: 17485074
- The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1. | Vale, C., et al. 2007. Cell Physiol Biochem. 20: 957-66. PMID: 17982278
- Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid. | Twiner, MJ., et al. 2008. Genomics. 91: 289-300. PMID: 18191373
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Azaspiracid-1, 0.5 µg | sc-202482A | 0.5 µg | $184.00 | |||
Azaspiracid-1, 1 µg | sc-202482 | 1 µg | $369.00 |