AZ20 (CAS 1233339-22-4)

AZ20 is a highly selective inhibitor targeting the ataxia telangiectasia mutated and Rad3-related (ATR) kinase, an enzyme pivotal in the DNA damage response and cell cycle regulation pathways. Through its inhibition of ATR kinase, AZ20 effectively disrupts the intricate network of signaling pathways that cells deploy in response to DNA damage, particularly during the S phase of the cell cycle. This interruption hampers the cell′s ability to repair DNA damage, leading to an accumulation of genomic instability and eventually, cell death. This mechanism positions AZ20 as useful in molecular biology and genetic research, enabling scientists to probe the complexities of DNA repair processes, investigate the cellular responses to genomic stress, and elucidate the role of ATR in maintaining genomic integrity. As such, AZ20 is extensively utilized in studies focused on understanding the fundamental mechanisms underlying DNA repair and cell cycle control, as well as in the development of new strategies for targeting cancer cells with compromised DNA repair capabilities.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences