Molecular structure of AY 9944, CAS Number: 366-93-8
AY 9944 (CAS 366-93-8)
See product citations (4)
Alternate Names:
trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride
Application:
AY 9944 is a hedgehog inhibitor and DHCR7 inhibitor
CAS Number:
366-93-8
Purity:
≥99%
Molecular Weight:
464.30
Molecular Formula:
C22H28Cl2N2•2HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AY 9944 is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. AY 9944 inhibits DHCR7 (Delta7-dehydrocholesterol reductase) (IC50 = 13 nM), thus reducing cholesterol biosynthesis, and also inhibiting cholesterol esterification. AY 9944 may also directly block the cellular response to hedgehog proteins. AY 9944 is an inhibitor of EBP.
AY 9944 (CAS 366-93-8) References
- Expression of Sonic Hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis. | Gofflot, F., et al. 2001. Dev Dyn. 220: 99-111. PMID: 11169843
- Brain sterols in the AY-9944 rat model of atypical absence seizures. | Cortez, MA., et al. 2002. Epilepsia. 43: 3-8. PMID: 11879380
- Serotonin depletion attenuates AY-9944-mediated atypical absence seizures. | Bercovici, E., et al. 2006. Epilepsia. 47: 240-6. PMID: 16499747
- GABA receptor proteins within lipid rafts in the AY-9944 model of atypical absence seizures. | Huo, JZ., et al. 2009. Epilepsia. 50: 776-88. PMID: 19054408
- Social deficits in the AY-9944 mouse model of atypical absence epilepsy. | Jung, S., et al. 2013. Behav Brain Res. 236: 23-29. PMID: 22944514
- Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs. | Yoshida, Y., et al. 1985. J Biochem. 98: 1669-79. PMID: 2419314
- Epileptic activity during early postnatal life in the AY-9944 model of atypical absence epilepsy. | Jung, S., et al. 2015. Cell Calcium. 57: 376-84. PMID: 25890840
- Neonatal exposure to AY-9944 increases typical spike and wave discharges in WAG/Rij and Wistar rats. | Perescis, MFJ., et al. 2019. Epilepsy Res. 157: 106184. PMID: 31539657
- Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944. | Kraml, M., et al. 1964. Biochem Biophys Res Commun. 15: 455-7. PMID: 4283982
- Effect of long-term administration of AY-9944, an inhibitor of 7-dehydrocholesterol delta 7-reductase, on serum and tissue lipids in the rat. | Dvornik, D. and Hill, P. 1968. J Lipid Res. 9: 587-95. PMID: 5726317
- Teratogenic effect of AY 9944 in rats: importance of the day of administration and maternal plasma cholesterol level. | Barbu, V., et al. 1984. Proc Soc Exp Biol Med. 176: 54-9. PMID: 6200888
- Molecular cloning and expression of the human delta7-sterol reductase. | Moebius, FF., et al. 1998. Proc Natl Acad Sci U S A. 95: 1899-902. PMID: 9465114
- Abnormal cholesterol biosynthesis produced by AY 9944 in the rat leads to skeletal deformities similar to the Smith-Lemli-Opitz syndrome. | Batta, AK. and Salen, G. 1998. J Lab Clin Med. 131: 192-3. PMID: 9523840
- Teratogen-mediated inhibition of target tissue response to Shh signaling. | Cooper, MK., et al. 1998. Science. 280: 1603-7. PMID: 9616123
- The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. | Incardona, JP., et al. 1998. Development. 125: 3553-62. PMID: 9716521
Inhibitor of:
DHCR7, and EBP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AY 9944, 5 mg | sc-202965 | 5 mg | $145.00 |