AXUD1 Antibody (2055E3a): sc-81191

AXUD1 Antibody (2055E3a) is a mouse monoclonal IgG1 antibody that detects AXUD1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-AXUD1 antibody (2055E3a) is available as a non-conjugated format. AXUD1 protein, also known as Axin-1 up-regulated gene 1 protein or TGF-β-induced apoptosis protein 3, plays a crucial role in cellular processes, particularly in apoptosis regulation. AXUD1 is predominantly localized in the nucleus, where AXUD1 influences gene expression related to cell survival and death. AXUD1 expression is notably elevated in response to wild-type Axin gene, which is significant given that Axin is a key regulator of beta-catenin, a protein involved in the Wnt signaling pathway that is often dysregulated in various cancers. Down-regulation of AXUD1 in kidney, lung, liver, and colon cancers compared to unaffected tissues suggests a potential function as a tumor suppressor, highlighting AXUD1′s importance in maintaining cellular homeostasis and preventing tumorigenesis. With widespread expression in tissues such as placenta, lung, skeletal muscle, leukocytes, and pancreas, AXUD1 may also have broader implications in developmental and immune processes, making AXUD1 a valuable target for research in cancer biology and therapeutic interventions.

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AXUD1 Antibody (2055E3a) References:

1. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.  |  Satoh, S., et al. 2000. Nat Genet. 24: 245-50. PMID: 10700176
2. Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney.  |  Ishiguro, H., et al. 2001. Oncogene. 20: 5062-6. PMID: 11526492
3. Transcriptional analysis of doxorubicin-induced cardiotoxicity.  |  Yi, X., et al. 2006. Am J Physiol Heart Circ Physiol. 290: H1098-102. PMID: 16243910
4. Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.  |  Hart, MJ., et al. 1998. Curr Biol. 8: 573-81. PMID: 9601641

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AXUD1 Antibody (2055E3a) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-AXUD1 Antibody (2055E3a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AXUD1 Antibody (2055E3a) Specifications

Alternate Product Name: AXUD1

Product Clone Name: 2055E3a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: AXUD1

Epitope Species: human

Product Reactivity/Detection: AXUD1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for AXUD1 Antibody (2055E3a): N/A