Molecular structure of Avermectin B1b, CAS Number: 65195-56-4
Avermectin B1b (CAS 65195-56-4)
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Application:
Avermectin B1b is a macrocyclic lactone and anthelmintic agent
CAS Number:
65195-56-4
Purity:
≥95%
Molecular Weight:
859.1
Molecular Formula:
C47H70O14
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Avermectin B1b is a product derived from the soil bacterium Streptomyces avermitilis. It is a member of the avermectin family of compounds. Avermectin B1b works by binding to glutamate-gated chloride channels in the nervous system of target organisms, leading to paralysis and death. This mechanism of action makes it highly effective against a wide range of parasites, including nematodes, mites, and insects.
Avermectin B1b (CAS 65195-56-4) References
- Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. | Wolstenholme, AJ. and Rogers, AT. 2005. Parasitology. 131 Suppl: S85-95. PMID: 16569295
- Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis. | Zhang, X., et al. 2006. Appl Microbiol Biotechnol. 72: 986-94. PMID: 16708195
- Production and Screening of High Yield Avermectin B1b Mutant of Streptomyces avermitilis 41445 Through Mutagenesis. | Siddique, S., et al. 2014. Jundishapur J Microbiol. 7: e8626. PMID: 25147669
- Antiviral effect of theaflavins against caliciviruses. | Ohba, M., et al. 2017. J Antibiot (Tokyo). 70: 443-447. PMID: 27756911
- Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. | Fritz, LC., et al. 1979. Proc Natl Acad Sci U S A. 76: 2062-6. PMID: 287043
- Abamectin:Avermectin (Pesticides). | ,. 2016. Food Saf (Tokyo). 4: 30-31. PMID: 32231902
- Characterization and optimization of abamectin-a powerful antiparasitic from a local Streptomyces avermitilis isolate. | Osman, YA., et al. 2020. Folia Microbiol (Praha).. PMID: 32323213
- Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects. | El-Saber Batiha, G., et al. 2020. Pharmaceuticals (Basel). 13: PMID: 32824399
- Stable Isotope Labeling by Carbon-13 in Bacteria Culture for the Analysis of Residual Avermectin Using Stable Isotope Dilution Liquid Chromatography Tandem Mass Spectrometry. | Beppu, K., et al. 2021. Anal Sci. 37: 1385-1390. PMID: 33716264
- Structural deformability induced in proteins of potential interest associated with COVID-19 by binding of homologues present in ivermectin: Comparative study based in elastic networks models. | González-Paz, L., et al. 2021. J Mol Liq. 340: 117284. PMID: 34421159
- Comparative study of the interaction of ivermectin with proteins of interest associated with SARS-CoV-2: A computational and biophysical approach. | González-Paz, L., et al. 2021. Biophys Chem. 278: 106677. PMID: 34428682
- Interaction of the new inhibitor paxlovid (PF-07321332) and ivermectin with the monomer of the main protease SARS-CoV-2: A volumetric study based on molecular dynamics, elastic networks, classical thermodynamics and SPT. | Alvarado, YJ., et al. 2022. Comput Biol Chem. 99: 107692. PMID: 35640480
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Avermectin B1b, 1 mg | sc-202071 | 1 mg | $700.00 | |||
Avermectin B1b, 1 mg | sc-202071-CW | 1 mg | $750.00 |