Avermectin B1a (CAS 65195-55-3)
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Avermectin B1a is a macrocyclic lactone. It is of interest in agricultural research and pest management due to its potent action as an insecticide and nematocide. The compound operates through a unique mechanism of action, targeting the neurotransmission processes in pests. Specifically, avermectin B1a binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates, leading to an increase in the permeability of the cell membrane to chloride ions. This influx of chloride ions causes hyperpolarization of the nerve cell, ultimately resulting in paralysis and death of the targeted organism. Its remarkable efficacy at low concentrations against a wide range of agricultural pests underpins its role in integrated pest management programs, aiming to reduce the reliance on traditional chemical pesticides and to minimize environmental impact. In research, avermectin B1a serves as a model compound for studying the bioactivity of similar macrocyclic lactones and for the development of new derivatives with enhanced activity and safety profiles, contributing to the advancement of sustainable agricultural practices.
Avermectin B1a (CAS 65195-55-3) References
- Bioaccumulation and elimination of avermectin B1a in the earthworms (Eisenia fetida). | Sun, Y., et al. 2005. Chemosphere. 60: 699-704. PMID: 15963808
- Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. | Wolstenholme, AJ. and Rogers, AT. 2005. Parasitology. 131 Suppl: S85-95. PMID: 16569295
- Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans. | Cully, DF. and Paress, PS. 1991. Mol Pharmacol. 40: 326-32. PMID: 1875915
- Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology. | Gao, H., et al. 2009. Bioresour Technol. 100: 4012-6. PMID: 19356927
- Novel mutation breeding method for Streptomyces avermitilis using an atmospheric pressure glow discharge plasma. | Wang, LY., et al. 2010. J Appl Microbiol. 108: 851-858. PMID: 19735332
- Effect of avermectin B1a on chick neuronal gamma-aminobutyrate receptor channels expressed in Xenopus oocytes. | Sigel, E. and Baur, R. 1987. Mol Pharmacol. 32: 749-52. PMID: 2447480
- Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. | Fritz, LC., et al. 1979. Proc Natl Acad Sci U S A. 76: 2062-6. PMID: 287043
- Avermectin B1a production in Streptomyces avermitilis is enhanced by engineering aveC and precursor supply genes. | Hao, Y., et al. 2022. Appl Microbiol Biotechnol. 106: 2191-2205. PMID: 35258669
- Efficacy of avermectin B1a against microfilariae of Dirofilaria immitis. | Blair, LS. and Campbell, WC. 1979. Am J Vet Res. 40: 1031-2. PMID: 507489
- Avermectin B1a, a paralyzing anthelmintic that affects interneurons and inhibitory motoneurons in Ascaris. | Kass, IS., et al. 1980. Proc Natl Acad Sci U S A. 77: 6211-5. PMID: 6255481
- Postsynaptic inhibition of invertebrate neuromuscular transmission by avermectin B1a. | Mellin, TN., et al. 1983. Neuropharmacology. 22: 89-96. PMID: 6302548
- Avermectin B1a binds to high- and low-affinity sites with dual effects on the gamma-aminobutyric acid-gated chloride channel of cultured cerebellar granule neurons. | Huang, J. and Casida, JE. 1997. J Pharmacol Exp Ther. 281: 261-6. PMID: 9103505
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Avermectin B1a, 1 mg | sc-202070 | 1 mg | $169.00 | |||
Avermectin B1a, 1 mg | sc-202070-CW | 1 mg | $322.00 | |||
Avermectin B1a, 25 mg | sc-202070A | 25 mg | $980.00 |