AVEN Antibody (48): sc-136455

AVEN Antibody (48) is a mouse monoclonal IgG1 kappa light chain antibody that detects AVEN protein of mouse, rat, human, and canine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-AVEN antibody (48) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). AVEN protein plays a critical role as a cell death regulator, functioning as a vital signal inducer in acute leukemias. AVEN protein is a highly conserved peripheral membrane protein that protects cells from apoptosis by inhibiting the proteolytic activation of caspases and disrupting Apaf-1′s self-association, which is essential for the apoptotic process. AVEN protein′s interaction with other proteins, such as Bcl-2 and Bad, further underscores its importance in preventing apoptosis, making AVEN protein a key player in cellular survival mechanisms. AVEN protein is predominantly expressed in tissues such as the ovary, heart, thymus, spleen, testis, and colon, with expression levels influenced by factors like erythropoietin and methylprednisolone, particularly in cardiac tissue following traumatic brain injury. Notably, in young patients with acute lymphoblastic leukemia, AVEN protein expression may serve as a valuable prognostic marker, highlighting its potential significance in clinical settings.

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AVEN Antibody (48) References:

1. Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.  |  Chau, BN., et al. 2000. Mol Cell. 6: 31-40. PMID: 10949025
2. Survivin and aven: two distinct antiapoptotic signals in acute leukemias.  |  Paydas, S., et al. 2003. Ann Oncol. 14: 1045-50. PMID: 12853345
3. Expression of the mouse Aven gene during spermatogenesis, analyzed by subtraction screening using Mvh-knockout mice.  |  Ina, S., et al. 2003. Gene Expr Patterns. 3: 635-8. PMID: 12971998
4. Aven and Bcl-xL enhance protection against apoptosis for mammalian cells exposed to various culture conditions.  |  Figueroa, B., et al. 2004. Biotechnol Bioeng. 85: 589-600. PMID: 14966800
5. International board certification in dermatopathology: paving the way for the future.  |  Kerl, H., et al. 2004. Am J Dermatopathol. 26: 439-40. PMID: 15365377
6. Aven overexpression: association with poor prognosis in childhood acute lymphoblastic leukemia.  |  Choi, J., et al. 2006. Leuk Res. 30: 1019-25. PMID: 16388850
7. Combining caspase and mitochondrial dysfunction inhibitors of apoptosis to limit cell death in mammalian cell cultures.  |  Sauerwald, TM., et al. 2006. Biotechnol Bioeng. 94: 362-72. PMID: 16598795
8. Expression of antiapoptotic survivin and aven genes in rat heart tissue after traumatic brain injury.  |  Ozisik, K., et al. 2006. Transplant Proc. 38: 2784-7. PMID: 17112829
9. Apoptosis-inhibitor Aven is downregulated in defective spermatogenesis and a novel estrogen target gene in mammalian testis.  |  Laurentino, S., et al. 2011. Fertil Steril. 96: 745-50. PMID: 21718987
10. The Apaf-1-binding protein Aven is cleaved by Cathepsin D to unleash its anti-apoptotic potential.  |  Melzer, IM., et al. 2012. Cell Death Differ. 19: 1435-45. PMID: 22388353
11. MicroRNA-30a contributes to pre-eclampsia through regulating the proliferation, apoptosis, and angiogenesis modulation potential of mesenchymal stem cells by targeting AVEN.  |  Gu, F., et al. 2022. Bioengineered. 13: 8724-8734. PMID: 35322749
12. Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression.  |  Li, X., et al. 2022. Mol Med Rep. 26: PMID: 35795990

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AVEN Antibody (48) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-AVEN Antibody (48) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AVEN Antibody (48) Specifications

Alternate Product Name: AVEN

Product Clone Name: 48

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 262-362

Epitope Target: AVEN

Epitope Species: human

Product Reactivity/Detection: AVEN

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for AVEN Antibody (48): AC: Agarose, HRP: Horseradish Peroxidase