Autophagy Inducer, STF-62247 (CAS 315702-99-9)
See product citations (3)
QUICK LINKS
Autophagy Inducer, STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice. STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations (IC50 = 16 μM). Selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 μM in RCC4 and RCC4/VHL killing, respectively) and in mice. Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
Autophagy Inducer, STF-62247 (CAS 315702-99-9) References
- A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. | Turcotte, S., et al. 2008. Cancer Cell. 14: 90-102. PMID: 18598947
- Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death. | Turcotte, S., et al. 2008. Autophagy. 4: 944-6. PMID: 18769110
- Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. | Chan, DA. and Giaccia, AJ. 2008. Cell Cycle. 7: 2987-90. PMID: 18818511
- Quantitative proteomics to study a small molecule targeting the loss of von Hippel-Lindau in renal cell carcinomas. | Bouhamdani, N., et al. 2017. Int J Cancer. 141: 778-790. PMID: 28486780
- The small molecule STF-62247 induces apoptotic and autophagic cell death in leukemic cells. | Kozako, T., et al. 2018. Oncotarget. 9: 27645-27655. PMID: 29963226
- Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells. | Zielke, S., et al. 2018. Cell Death Dis. 9: 994. PMID: 30250198
- STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts. | Kinzler, MN., et al. 2020. Sci Rep. 10: 687. PMID: 31959760
- On-Demand Autophagy Cascade Amplification Nanoparticles Precisely Enhanced Oxaliplatin-Induced Cancer Immunotherapy. | Wang, X., et al. 2020. Adv Mater. 32: e2002160. PMID: 32596861
- Advances in autophagy as a target in the treatment of tumours. | Li, Y., et al. 2022. J Drug Target. 30: 166-187. PMID: 34319838
- Tailor-Made Autophagy Cascade Amplification Polymeric Nanoparticles for Enhanced Tumor Immunotherapy. | Long, X., et al. 2023. Small. e2207898. PMID: 36932938
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Autophagy Inducer, STF-62247, 10 mg | sc-203831 | 10 mg | $163.00 | |||
Autophagy Inducer, STF-62247, 25 mg | sc-203831A | 25 mg | $347.00 | |||
Autophagy Inducer, STF-62247, 50 mg | sc-203831B | 50 mg | $551.00 |