Date published: 2025-11-23

1-800-457-3801

SCBT Portrait Logo
Seach Input

Autocamtide-2-Related Inhibitory Peptide (CAS 167114-91-2)

5.0(1)
Write a reviewAsk a question

Alternate Names:
CaM kinase II inhibitor TFA salt
Application:
Autocamtide-2-Related Inhibitory Peptide is a highly specific and potent inhibitor of CaMKII
CAS Number:
167114-91-2
Molecular Weight:
1611.76
Molecular Formula:
C64H116N22O19•C2HF3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Autocamtide-2-Related Inhibitory Peptide is a synthetic peptide that plays a significant role in the study of cellular signaling pathways. It is primarily used as an inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII), an enzyme that is in the regulation of numerous physiological processes including memory formation, synaptic plasticity, and cellular excitability. Researchers utilize this peptide to dissect the specific contributions of CaMKII to these complex signaling cascades and to understand its function in various cellular contexts. In neuroscience research, Autocamtide-2-Related Inhibitory Peptide provides a means to study the modulation of neuronal activity and plasticity. Additionally, in the field of molecular biology, it is used to investigate the downstream effects of CaMKII inhibition on gene expression and protein synthesis. The peptide′s role in signaling research is also extended to studies of cardiomyocyte function.


Autocamtide-2-Related Inhibitory Peptide (CAS 167114-91-2) References

  1. Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban.  |  DeSantiago, J., et al. 2002. J Mol Cell Cardiol. 34: 975-84. PMID: 12234767
  2. Oxidative-induced calcium mobilization is dependent on annexin VI release from lipid rafts.  |  Cuschieri, J., et al. 2005. Surgery. 138: 158-64. PMID: 16153422
  3. Glutamate-induced NFkappaB activation in the retina.  |  Fan, W. and Cooper, NG. 2009. Invest Ophthalmol Vis Sci. 50: 917-25. PMID: 18836176
  4. A role for calcium-calmodulin-dependent protein kinase II in the consolidation of visual object recognition memory.  |  Tinsley, CJ., et al. 2009. Eur J Neurosci. 30: 1128-39. PMID: 19735285
  5. Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia.  |  Liu, N., et al. 2011. J Mol Cell Cardiol. 50: 214-22. PMID: 20937285
  6. Selective modulation of coupled ryanodine receptors during microdomain activation of calcium/calmodulin-dependent kinase II in the dyadic cleft.  |  Dries, E., et al. 2013. Circ Res. 113: 1242-52. PMID: 24081880
  7. Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiforme.  |  Sun, X., et al. 2013. Oncol Rep. 30: 2852-8. PMID: 24100685
  8. CaMKII Regulates Synaptic NMDA Receptor Activity of Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension.  |  Li, DP., et al. 2017. J Neurosci. 37: 10690-10699. PMID: 28972129
  9. Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca2+-Activated K+ Current in Patients with Chronic Atrial Fibrillation.  |  Fan, X., et al. 2018. Med Sci Monit. 24: 3011-3023. PMID: 29737974
  10. Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II.  |  Bezzerides, VJ., et al. 2019. Circulation. 140: 405-419. PMID: 31155924
  11. The CaMKII phosphorylation site Thr1604 in the CaV1.2 channel is involved in pathological myocardial hypertrophy in rats.  |  Li, J., et al. 2020. Channels (Austin). 14: 151-162. PMID: 32290730
  12. Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways.  |  Hegyi, B., et al. 2020. Basic Res Cardiol. 115: 71. PMID: 33237428
  13. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II.  |  Ishida, A., et al. 1995. Biochem Biophys Res Commun. 212: 806-12. PMID: 7626114

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Autocamtide-2-Related Inhibitory Peptide, 1 mg

sc-364668
1 mg
$158.00

What is the solubility of this product in water?

Asked by: hawkeye11
Thank you for your question. The solubility for this product is 1 mg/ml in water. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-22
  • y_2025, m_11, d_14, h_6CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_364668, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 101ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Ishida A; et alIshida A; et al. (PubMed ID: 7626114) determined that Autocamtide-2-Related Inhibitory Peptide was a powerful and specific calmodulin-dependent protein kinase II inhibitor. -SCBT Publication Review
Date published: 2015-06-23
  • y_2025, m_11, d_14, h_6
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_364668, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 14ms
  • REVIEWS, PRODUCT
Autocamtide-2-Related Inhibitory Peptide is rated 5.0 out of 5 by 1.
  • y_2025, m_11, d_14, h_6
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_364668, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 111ms
  • REVIEWS, PRODUCT