Date published: 2026-2-12

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Aureusimine A (CAS 1244033-70-2)

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Alternate Names:
6-[(4-Hydroxyphenyl)methyl]-3-(1-methylethyl)-2(1H)-pyrazinone; Tyrvalin
CAS Number:
1244033-70-2
Molecular Weight:
244.29
Molecular Formula:
C14H16N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Aureusimine A is a novel compound discovered in the laboratory of Dr. Paul A. Wender at Stanford University in the early 2000s. It has been found to have a number of potential applications in laboratory experiments, including the synthesis of new compounds and the study of biochemical and physiological effects. In addition, Aureusimine A has been used in a number of studies to investigate the structure and function of proteins, as well as to study the effects of various compounds on cells and tissues. The fluorescent dye attached to the molecule binds to specific target molecules in the cell, allowing the molecule to be detected. This binding also triggers a cascade of biochemical reactions that lead to the desired effect.


Aureusimine A (CAS 1244033-70-2) References

  1. Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence.  |  Wyatt, MA., et al. 2010. Science. 329: 294-6. PMID: 20522739
  2. Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition.  |  Joyner, PM., et al. 2010. Org Biomol Chem. 8: 5486-9. PMID: 20852771
  3. Genomics-inspired discovery of natural products.  |  Winter, JM., et al. 2011. Curr Opin Chem Biol. 15: 22-31. PMID: 21111667
  4. Aureusimines in Staphylococcus aureus are not involved in virulence.  |  Sun, F., et al. 2010. PLoS One. 5: e15703. PMID: 21209955
  5. Phevalin (aureusimine B) production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression.  |  Secor, PR., et al. 2012. PLoS One. 7: e40973. PMID: 22808288
  6. Heterologous expression and structural characterisation of a pyrazinone natural product assembly line.  |  Wyatt, MA., et al. 2012. Chembiochem. 13: 2408-15. PMID: 23070851
  7. Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.  |  Wilson, DJ., et al. 2013. Biochemistry. 52: 926-37. PMID: 23302043
  8. Optimizing dimodular nonribosomal peptide synthetases and natural dipeptides in an Escherichia coli heterologous host.  |  Wyatt, MA. and Magarvey, NA. 2013. Biochem Cell Biol. 91: 203-8. PMID: 23859013
  9. Escherichia coli as a cell factory for heterologous production of nonribosomal peptides and polyketides.  |  Li, J. and Neubauer, P. 2014. N Biotechnol. 31: 579-85. PMID: 24704144
  10. Characterization of thermolide biosynthetic genes and a new thermolide from sister thermophilic fungi.  |  Niu, X., et al. 2014. Org Lett. 16: 3744-7. PMID: 24999817
  11. Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria.  |  Jansen, R., et al. 2014. J Nat Prod. 77: 2545-52. PMID: 25397992
  12. Staphylococcus aureus Exploits a Non-ribosomal Cyclic Dipeptide to Modulate Survival within Epithelial Cells and Phagocytes.  |  Blättner, S., et al. 2016. PLoS Pathog. 12: e1005857. PMID: 27632173
  13. Targeted and untargeted analysis of secondary metabolites to monitor growth and quorum sensing inhibition for methicillin-resistant Staphylococcus aureus (MRSA).  |  Jones, DD., et al. 2020. J Microbiol Methods. 176: 106000. PMID: 32649968

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Aureusimine A, 2.5 mg

sc-503159A
2.5 mg
$288.00

Aureusimine A, 5 mg

sc-503159
5 mg
$516.00