Date published: 2026-2-13

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Aureusidin (CAS 38216-54-5)

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Alternate Names:
(2Z)-2-[(3,4-dihydroxyphenyl)methylene]-4,6-dihydroxy-3(2H)-benzofuranone; Cernuin
CAS Number:
38216-54-5
Molecular Weight:
286.24
Molecular Formula:
C15H10O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Aureusidin is a natural compound belonging to the class of flavonoids, specifically a type of aurone. Like many flavonoids, it exhibits antioxidant properties, capable of scavenging free radicals and potentially mitigating oxidative stress within biological systems. It has been employed in studies exploring enzyme inhibition, protein folding, and DNA binding. Furthermore, it has been utilized to investigate the impact of oxidative stress and inflammation. Aureusidin is responsible for the yellow pigmentation in the petals of some flower varieties, contributing to their aesthetic appeal and playing a role in attracting pollinators. It is synthesized through the phenylpropanoid pathway, which also leads to the production of other types of flavonoids and related compounds. Like many flavonoids, it exhibits antioxidant properties, capable of scavenging free radicals and potentially mitigating oxidative stress within biological systems.


Aureusidin (CAS 38216-54-5) References

  1. Enzymatic formation of aurones in the extracts of yellow snapdragon flowers.  |  Sato, T., et al. 2001. Plant Sci. 160: 229-236. PMID: 11164594
  2. The cooccurrence of different biflavonoid types in Pilotrichella flexilis.  |  Brinkmeier, E., et al. 2000. Z Naturforsch C J Biosci. 55: 866-9. PMID: 11204186
  3. Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity.  |  Detsi, A., et al. 2009. Bioorg Med Chem. 17: 8073-85. PMID: 19853459
  4. Altered leaf colour is associated with increased superoxide-scavenging activity in aureusidin-producing transgenic plants.  |  Shakya, R., et al. 2012. Plant Biotechnol J. 10: 1046-55. PMID: 22924954
  5. Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora.  |  Shrestha, S., et al. 2013. Bioorg Med Chem Lett. 23: 5150-4. PMID: 23927974
  6. Anti-inflammatory effects of Aureusidin in LPS-stimulated RAW264.7 macrophages via suppressing NF-κB and activating ROS- and MAPKs-dependent Nrf2/HO-1 signaling pathways.  |  Ren, J., et al. 2020. Toxicol Appl Pharmacol. 387: 114846. PMID: 31790703
  7. The Mechanism of Aureusidin in Suppressing Inflammatory Response in Acute Liver Injury by Regulating MD2.  |  Yang, Y., et al. 2020. Front Pharmacol. 11: 570776. PMID: 33192512
  8. Metabolomic Elucidation of the Effect of Sucrose on the Secondary Metabolite Profiles in Melissa officinalis by Ultraperformance Liquid Chromatography-Mass Spectrometry.  |  Kim, S., et al. 2020. ACS Omega. 5: 33186-33195. PMID: 33403280
  9. Aureusidin derivative CNQX inhibits chronic colitis inflammation and mucosal barrier damage by targeting myeloid differentiation 2 protein.  |  Yang, Y., et al. 2021. J Cell Mol Med. 25: 7257-7269. PMID: 34184406
  10. Characterization of Flavonoids and Transcripts Involved in Their Biosynthesis in Different Organs of Cissus rotundifolia Lam.  |  Gichuki, DK., et al. 2021. Metabolites. 11: PMID: 34822399
  11. Corrigendum: The Mechanism of Aureusidin in Suppressing Inflammatory Response in Acute Liver Injury by Regulating MD2.  |  Yang, Y., et al. 2021. Front Pharmacol. 12: 802304. PMID: 34938199
  12. Genetic engineering of novel yellow color african violet (Saintpaulia ionantha) produced by accumulation of Aureusidin 6-O-glucoside.  |  Rajabi, A., et al. 2022. Biol Proced Online. 24: 3. PMID: 35139820
  13. Assessment of the Hypoglycemic and Hypolipidemic Activity of Flavonoid-Rich Extract from Angelica keiskei.  |  Tu, L., et al. 2022. Molecules. 27: PMID: 36235163
  14. Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Bushen Hugu Decoction in the Treatment of Malignant Tumor Bone Metastases.  |  Sang, T., et al. 2022. Biomed Res Int. 2022: 2055900. PMID: 36440359
  15. Unveiling the inhibitory mechanism of aureusidin targeting xanthine oxidase by multi-spectroscopic methods and molecular simulations.  |  He, P., et al. 2023. RSC Adv. 13: 1606-1616. PMID: 36688063

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Aureusidin, 2.5 mg

sc-503158
2.5 mg
$388.00