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AUDA is an inhibitor of soluble epoxide hydrolase (sEH, IC50 = 18 nM in mice). AUDA has been shown to demonstrate hypotensive effects, accompanied by an increase in urinary epoxide-to-diol ratios. At a concentration of 10 μM, AUDA is able to activate peroxisome proliferator-activated receptor α (PPARα) 3-fold, while showing no ability to affect PPARδ or PPARγ.
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2. Fleming, Ingrid., et al., 2004. Cytochrome P450 epoxygenases as EDHF synthase(s). Pharmacological research : the official journal of the Italian Pharmacological Society. 49(6): 525-33. PMID: 15026030
3. Fang, Xiang., et al., 2005. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. The Journal of pharmacology and experimental therapeutics. 314(1): 260-70. PMID: 15798002
4. Imig, John D., et al., 2005. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension. 46(4): 975-81. PMID: 16157792
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