AUDA CAS: 479413-70-2
MF: C23H40N2O3
MW: 392.58
An inhibitor of sEH and selective activator of PPARα.

AUDA (CAS 479413-70-2)

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Synonym: 12-[[(tricyclo[,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
Application: An inhibitor of sEH and selective activator of PPARα
CAS Number: 479413-70-2
Purity: ≥98%
Molecular Weight: 392.58
Molecular Formula: C23H40N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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AUDA is an inhibitor of soluble epoxide hydrolase (sEH, IC50 = 18 nM in mice). AUDA has been shown to demonstrate hypotensive effects, accompanied by an increase in urinary epoxide-to-diol ratios. At a concentration of 10 μM, AUDA is able to activate peroxisome proliferator-activated receptor α (PPARα) 3-fold, while showing no ability to affect PPARδ or PPARγ.


1. Morisseau, Christophe., et al., 2002. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochemical pharmacology. 63(9): 1599-608. PMID: 12007563
2. Fleming, Ingrid., et al., 2004. Cytochrome P450 epoxygenases as EDHF synthase(s). Pharmacological research : the official journal of the Italian Pharmacological Society. 49(6): 525-33. PMID: 15026030
3. Fang, Xiang., et al., 2005. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. The Journal of pharmacology and experimental therapeutics. 314(1): 260-70. PMID: 15798002
4. Imig, John D., et al., 2005. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension. 46(4): 975-81. PMID: 16157792

Physical State :
Solubility :
Soluble in water (0.5 mg/ml at 25° C), 100% ethanol (4 mg/ml), DMSO (≥ 10 mg/ml at 60° C), DMF (~2 mg/ml), and DMF : PBS (pH 7.2) (1:1) (~0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
228.39° C (Predicted)
Boiling Point :
~592.7° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
IC50 :
Epoxide hydrolase 2: IC50 = 5 nM (rat); sEH: IC50 = 18 nM (mouse); sEH: IC50 = 69 nM (human)
pK Values :
pKa: 4.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

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