atrophin-2 Antibody (REREF1H8): sc-81115

atrophin-2 Antibody (REREF1H8) is a mouse monoclonal IgG2b antibody that detects atrophin-2 protein of human origin by western blotting (WB) and immunoprecipitation (IP). anti-atrophin-2 antibody (REREF1H8) is available as a non-conjugated format. Atrophin-2, also known as Arginine-glutamic acid dipeptide repeats protein or Atrophin-1-like protein, is a 1,566 amino acid protein encoded by the human gene RERE. This protein belongs to the atrophin family, characterized by arginine-glutamic acid (RE) dipeptide repeats, and features a complex structure including one BAH domain, one ELM2 domain, one GATA-type zinc finger, and one SANT domain. The structural composition of atrophin-2 enables functioning as a transcriptional repressor during development, which regulates gene expression and ensures proper cellular differentiation. Atrophin-2 plays a significant role in cell survival; overexpression can lead to Bax recruitment to the nucleus, particularly to the promyelocytic leukemia (PML) nuclear body, triggering caspase-3 activation and resulting in cell death. Atrophin-2 interacts with proteins such as HDAC1 and atrophin-1, with atrophin-1 interaction being enhanced when poly-Gln region of atrophin-1 is extended, highlighting the importance of these interactions in cellular processes.

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atrophin-2 Antibody (REREF1H8) References:

1. Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis.  |  Waerner, T., et al. 2001. Cell Growth Differ. 12: 201-10. PMID: 11331249
2. PODs in the nuclear spot: enigmas in the magician's pot.  |  Hatta, M. and Fukamizu, A. 2001. Sci STKE. 2001: pe1. PMID: 11752673
3. Grunge, related to human Atrophin-like proteins, has multiple functions in Drosophila development.  |  Erkner, A., et al. 2002. Development. 129: 1119-29. PMID: 11874908
4. Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.  |  Zoltewicz, JS., et al. 2004. Development. 131: 3-14. PMID: 14645126
5. Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors.  |  Wang, L., et al. 2006. Genes Dev. 20: 525-30. PMID: 16481466
6. Neuroblastoma tumors with favorable and unfavorable outcomes: Significant differences in mRNA expression of genes mapped at 1p36.2.  |  Fransson, S., et al. 2007. Genes Chromosomes Cancer. 46: 45-52. PMID: 17044048
7. Functional architecture of atrophins.  |  Shen, Y., et al. 2007. J Biol Chem. 282: 5037-5044. PMID: 17150957
8. REREa/Atrophin-2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development.  |  Plaster, N., et al. 2007. Dev Dyn. 236: 1891-904. PMID: 17576618

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-atrophin-2 Antibody (REREF1H8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-atrophin-2 Antibody (REREF1H8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

atrophin-2 Antibody (REREF1H8) Specifications

Alternate Product Name: atrophin-2

Product Clone Name: REREF1H8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: atrophin-2

Epitope Species: human

Product Reactivity/Detection: atrophin-2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for atrophin-2 Antibody (REREF1H8): N/A